Photochemical reactions are an attractive foundation for the synthesis of radiolabelled antibodies, immunoglobulin fragments and other proteins/peptides. The synthesis, 68Ga-radiochemistry and photochemical reactivity of three macrocyclic chelates functionalised with an arylazide group is described. Experiments with trastuzumab confirmed that photoradiochemistry facilitates fast, one-pot synthesis of radiolabelled proteins.
L. S. Eichenberger, M. Patra and J. P. Holland, Chem. Commun., 2019, 55, 2257 DOI: 10.1039/C8CC09660K
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