Issue 36, 2019

Dynamic protein hydrogels with reversibly tunable stiffness regulate human lung fibroblast spreading reversibly

Abstract

We report the engineering of a protein-based dynamic hydrogel that can be reversibly tuned between stiff and soft states via a redox reaction. When cultured on this hydrogel surface, human lung fibroblasts can dynamically and reversibly change their morphology in response to changes in hydrogel stiffness.

Graphical abstract: Dynamic protein hydrogels with reversibly tunable stiffness regulate human lung fibroblast spreading reversibly

Supplementary files

Article information

Article type
Communication
Submitted
14 Feb 2019
Accepted
04 Apr 2019
First published
04 Apr 2019

Chem. Commun., 2019,55, 5235-5238

Dynamic protein hydrogels with reversibly tunable stiffness regulate human lung fibroblast spreading reversibly

L. Fu, A. Haage, N. Kong, G. Tanentzapf and H. Li, Chem. Commun., 2019, 55, 5235 DOI: 10.1039/C9CC01276A

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