A small-molecule probe for ratiometric photoacoustic imaging of hydrogen sulfide in living mice

Xiang Li; Yufu Tang; Jie Li; Xiaoming Hu; Chao Yin; Zhen Yang; Qi Wang; Zizi Wu; Xiaomei Lu; Wenjun Wang; Wei Huang; Quli Fan

doi:10.1039/C9CC02224D

A small-molecule probe for ratiometric photoacoustic imaging of hydrogen sulfide in living mice†

Xiang Li,^a Yufu Tang,^a Jie Li,^a Xiaoming Hu,^a Chao Yin,^a Zhen Yang,^a Qi Wang,^a Zizi Wu,^b Xiaomei Lu,‡*^b Wenjun Wang,^c Wei Huang^ab and Quli Fan

*^a

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* Corresponding authors

^a Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China
E-mail: iamqlfan@njupt.edu.cn

^b Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University (NanjingTech), Nanjing 211816, China

^c Key Lab of Optical Communication Science and Technology of Shandong Province & School of Physics Science and Information Engineering, Liaocheng University, Liaocheng 252059, China

Abstract

A small-molecule photoacoustic probe based on cyanine dyes was developed by taking advantage of the nucleophilic substitution reaction of H₂S with chlorine. The probe demonstrated specific response to H₂S with ratiometric photoacoustic signals in the NIR region, which enabled real-time, accurate, high-resolution imaging of endogenous H₂S in vivo.

Chemical Communications

A small-molecule probe for ratiometric photoacoustic imaging of hydrogen sulfide in living mice†

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A small-molecule probe for ratiometric photoacoustic imaging of hydrogen sulfide in living mice

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