Issue 60, 2019
From the journal:

Chemical Communications

Multi-component heteroarene couplings via polarity-reversed radical cascades†

Jeremy M. Lear,‡a   J. Quentin Buquoi,‡a   Xin Gu,a   Kui Pan,a   Darsheed N. Mustafaa  and  David A. Nagib ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA
E-mail: nagib.1@osu.edu

Abstract

A multi-component radical addition strategy enables difunctionalization of alkenes with heteroarenes and a variety of radical precursors, including N3, P(O)R2, and CF3. This unified approach for coupling diverse classes of electrophilic radicals and heteroarenes to vinyl ethers allows for direct, vicinal C–C as well as C–N, C–P, and C–Rf bond formation.

Graphical abstract: Multi-component heteroarene couplings via polarity-reversed radical cascades

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Article information

DOI
https://doi.org/10.1039/C9CC03498F
Article type
Communication
Submitted
07 May 2019
Accepted
21 May 2019
First published
21 May 2019

Chem. Commun., 2019,55, 8820-8823

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Multi-component heteroarene couplings via polarity-reversed radical cascades

J. M. Lear, J. Q. Buquoi, X. Gu, K. Pan, D. N. Mustafa and D. A. Nagib, Chem. Commun., 2019, 55, 8820 DOI: 10.1039/C9CC03498F

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