Issue 13, 2019
From the journal:

CrystEngComm

Co-crystallization and polymorphic behaviour of 5-fluorouracil†

Dennis D. Enkelmann,a   Jens Handelmann,b   Carsten Schauertec  and  Klaus Merz ORCID logo *b  

* Corresponding authors

a Institute of Pharmacy, University of Innsbruck, Innrain 52c, 6020 Innsbruck, Austria

b Inorganic Chemistry I – Bioinorganic Chemistry, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Universitätsstrasse 150, 44797 Bochum, Germany
E-mail: Klaus.merz@rub.de

c Solid-Chem GmbH, Universitätstrasse 136, 44799 Bochum, Germany

Abstract

Syntheses and single-crystal characterization of two co-crystalline 5-fluorouracil compounds with nontoxic co-formers of the GRAS list, succinic acid and adipic acid, are presented. Furthermore, the target-oriented synthon approach from methanol or ethanol (technical grade) to polymorphic form II, which is hitherto only accessible from dry nitromethane, is described.

Graphical abstract: Co-crystallization and polymorphic behaviour of 5-fluorouracil

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C8CE01692E
Article type
Paper
Submitted
05 Oct 2018
Accepted
12 Nov 2018
First published
13 Nov 2018

CrystEngComm, 2019,21, 2130-2134

Permissions

Request permissions

Co-crystallization and polymorphic behaviour of 5-fluorouracil

D. D. Enkelmann, J. Handelmann, C. Schauerte and K. Merz, CrystEngComm, 2019, 21, 2130 DOI: 10.1039/C8CE01692E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements