Issue 11, 2019
From the journal:

Dalton Transactions

A platinum(iv) prodrug to defeat breast cancer through disrupting vasculature and inhibiting metastasis†

Yan Guo,‡a   Shuren Zhang,‡a   Hao Yuan,a   Dongfan Song,a   Suxing Jin, ORCID logo b   Zijian Guo ORCID logo *a  and  Xiaoyong Wang ORCID logo *b  

* Corresponding authors

a State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China
E-mail: zguo@nju.edu.cn
Fax: +86 25 83314502
Tel: +86 25 83594549

b State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, P. R. China
E-mail: boxwxy@nju.edu.cn
Fax: +86 25 83314502
Tel: +86 25 83594549

Abstract

A PtIV prodrug (PDMA) exhibits great potential for the therapy of metastatic triple-negative breast cancer (TNBC) through a synergistic action of antiangiogensis and antimetastasis.

Graphical abstract: A platinum(iv) prodrug to defeat breast cancer through disrupting vasculature and inhibiting metastasis

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Article information

DOI
https://doi.org/10.1039/C9DT00335E
Article type
Communication
Submitted
24 Jan 2019
Accepted
13 Feb 2019
First published
14 Feb 2019

Dalton Trans., 2019,48, 3571-3575

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A platinum(IV) prodrug to defeat breast cancer through disrupting vasculature and inhibiting metastasis

Y. Guo, S. Zhang, H. Yuan, D. Song, S. Jin, Z. Guo and X. Wang, Dalton Trans., 2019, 48, 3571 DOI: 10.1039/C9DT00335E

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