Issue 12, 2019

Cobalt catalyzed regioselective C–H methylation/acetoxylation of anilides: new routes for C–C and C–O bond formation

Abstract

The first cobalt-catalyzed regioselective C–H methylation/acetoxylation reactions of anilides using peroxides and acetic acid respectively as attacking reagents have been developed herein. This new strategy features low cost, high selectivity, a broad range of functional groups, use of green and low toxic DTBP and HOAc, and avoidance of extraneous directing groups, thus offering a good complement to previous C–H methylation/acetoxylation reactions and expanding the application of cobalt-catalyzed C–H activations. Mechanistic explorations into the reaction process are also described in detail.

Graphical abstract: Cobalt catalyzed regioselective C–H methylation/acetoxylation of anilides: new routes for C–C and C–O bond formation

Supplementary files

Article information

Article type
Research Article
Submitted
22 Mar 2019
Accepted
30 Apr 2019
First published
30 Apr 2019

Org. Chem. Front., 2019,6, 2043-2047

Cobalt catalyzed regioselective C–H methylation/acetoxylation of anilides: new routes for C–C and C–O bond formation

Z. Li, P. Wu and C. Cai, Org. Chem. Front., 2019, 6, 2043 DOI: 10.1039/C9QO00411D

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