Correction: Identification of selective protein–protein interaction inhibitors using efficient in silico peptide-directed ligand design

Abstract

Correction for ‘Identification of selective protein–protein interaction inhibitors using efficient in silico peptide-directed ligand design’ by Andrew M. Beekman et al., Chem. Sci., 2019, DOI: 10.1039/c9sc00059c.

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The authors regret that the structures of compounds 2, 3, 10 and 11 are incorrect in the original article. The correct structures are presented in the updated version of Table 1 below.

Table 1 IC₅₀ values for inhibition of the binding of FAM-p4 to hDM2 and hDMX of small molecules.^a A green background indicates the compound was designed for and was selective to the same protein. Yellow indicates the compound is a dual inhibitor. A red background indicates the compound was designed for one protein but was selective for the other protein

a IC₅₀ values determined by non-linear regression of at least three independent experiments (see ESI, pg 10). Errors are 95% confidence intervals (CI). Fmoc, 9-fluorenylmethylcarbonyl.

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The original ESI was replaced by a correspondingly revised version on 1st May 2019 to reflect these changes.

The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.

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Footnote

† Electronic supplementary information (ESI) available: See DOI: 10.1039/c9sc00059c

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