Convection-driven microfabricated hydrogels for rapid biosensing

Abstract

A microscale biosensing platform using rehydration-mediated swelling of bio-functionalized hydrogel structures and rapid target analyte capture is described. Induced convective flow mitigates diffusion limited incubation times, enabling model assays to be completed in under three minutes. Assay design parameters have been evaluated, revealing fabrication criteria required to tune detection sensitivity.