Issue 18, 2020

Recent advances in micro- and nano-bubbles for atherosclerosis applications

Abstract

Atherosclerosis is the most prevalent cause of cardiovascular disease-induced deaths worldwide. Micro- and nano-bubbles (MNBs) have been developed as the vehicles for detection, investigation, and drug delivery, specifically targeting atherosclerotic sites. MNBs have been clinically applied and commercialized as contrast agents because they typically respond to ultrasound for guiding and stimulating imaging. The assembly process involves some specific substrates (proteins, lipids, and polymers) to adjust their characteristics and depends upon rational designs for combined therapeutic-diagnostic (theranostic) applications. Ancillary surface modifications of MNBs enable the unification of MNBs with antibody, inflammatory markers, or genes to more specifically deliver cargos to the oxidized lipid-rich quarry area and release the payloads on demand to the lesion site. This review provides brief information on the process of fabricating MNBs and their applications in bio-nanomedicine for diagnosing and remodeling atherosclerosis.

Graphical abstract: Recent advances in micro- and nano-bubbles for atherosclerosis applications

Article information

Article type
Review Article
Submitted
09 May 2020
Accepted
09 Jul 2020
First published
16 Jul 2020

Biomater. Sci., 2020,8, 4920-4939

Recent advances in micro- and nano-bubbles for atherosclerosis applications

A. Wijaya, A. Maruf, W. Wu and G. Wang, Biomater. Sci., 2020, 8, 4920 DOI: 10.1039/D0BM00762E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements