Issue 62, 2020
From the journal:

Chemical Communications

Tuning the properties of atomically precise gold nanoclusters for biolabeling and drug delivery†

Man-Man Xu,‡a   Tong-Tong Jia,‡a   Bingjie Li,b   Wang Ma,b   Xiaoyuan Chen, ORCID logo c   Xueli Zhao*a  and  Shuang-Quan Zang ORCID logo *a  

* Corresponding authors

a Green Catalysis Center and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China
E-mail: xuelizhao@zzu.edu.cn, zangsqzg@zzu.edu.cn

b The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China

c Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA

Abstract

A structure-determined gold-levonorgestrel nanocluster, Au10(C21H27O2)10 (Au10NC), has been obtained via solvent induced crystal transformation from Au8(C21H27O2)8 (Au8NC), accompanied by a fluorescence color change from green to yellow. A cationic polymer, poly(allylamine hydrochloride) (PAH), was chosen to assemble with Au10NC to prepare monodisperse and stable particles (Au10NC-PAH) with an increased quantum yield of 49.8%. The as-fabricated Au10NC-PAH realized effective antibody-mediated actin imaging and sustained drug release.

Graphical abstract: Tuning the properties of atomically precise gold nanoclusters for biolabeling and drug delivery

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Article information

DOI
https://doi.org/10.1039/D0CC03498C
Article type
Communication
Submitted
16 May 2020
Accepted
22 Jun 2020
First published
23 Jun 2020

Chem. Commun., 2020,56, 8766-8769

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Tuning the properties of atomically precise gold nanoclusters for biolabeling and drug delivery

M. Xu, T. Jia, B. Li, W. Ma, X. Chen, X. Zhao and S. Zang, Chem. Commun., 2020, 56, 8766 DOI: 10.1039/D0CC03498C

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