Issue 21, 2020
From the journal:

Organic & Biomolecular Chemistry

NBD-based fluorescent probes for separate detection of cysteine and biothiols via different reactivities†

Haojie Huang,‡a   Xiuru Ji,‡b   Yaqing Jiang,a   Changyu Zhang,a   Xueying Kang,a   Jiqin Zhu,*a   Lu Sun ORCID logo *b  and  Long Yi ORCID logo a  

* Corresponding authors

a State Key Laboratory of Organic–Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, China
E-mail: zhujq@mail.buct.edu.cn

b Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China
E-mail: sunlu@tmu.edu.cn

Abstract

NBD-based fluorescent probes that can separately detect cysteine and biothiols via different reactivities have been rationally designed and synthesized. The probes can be applied to kinetically distinguish cysteine from other biothiols at 30 min, and to detect all biothiols at 3 h in living cells.

Graphical abstract: NBD-based fluorescent probes for separate detection of cysteine and biothiols via different reactivities

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Article information

DOI
https://doi.org/10.1039/D0OB00040J
Article type
Communication
Submitted
08 Jan 2020
Accepted
11 May 2020
First published
11 May 2020

Org. Biomol. Chem., 2020,18, 4004-4008

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NBD-based fluorescent probes for separate detection of cysteine and biothiols via different reactivities

H. Huang, X. Ji, Y. Jiang, C. Zhang, X. Kang, J. Zhu, L. Sun and L. Yi, Org. Biomol. Chem., 2020, 18, 4004 DOI: 10.1039/D0OB00040J

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