Gold catalyzed efficient preparation of dihydrobenzofuran from 1,3-enyne and phenol

Abstract

A gold catalyzed formal intermolecular [2+3] cyclo-coupling of 1,3-enynes with phenols was developed to prepare dihydrobenzofuran derivatives with the addition of 2,6-dichloropyridine N-oxide, in which, a highly ortho-selective phenol S_EAr functionalization was achieved by using 1,3-enynes as α-oxo vinyl gold carbenoid surrogates.