Issue 22, 2021

One-pot solvent-free extraction and formulation of lipophilic natural products: from curcuma to dried formulations of curcumin

Abstract

A new environmentally friendly process for the efficient extraction and formulation of lipophilic bioactive compounds from plants has been successfully developed. This study describes the application of this ultrasound-assisted technique to the simultaneous encapsulation and extraction of curcumin from Curcuma longa in a medium essentially composed of water with the addition of biocompatible oil and surfactant. The resulting curcuminoid-loaded emulsion was called “extremulsion” for extract-emulsion. The composition of the extractant medium and ultrasonic parameters were studied to obtain optimal extremulsions in terms of droplet size, stability and curcumin-loading. Extremulsions comprising droplets with a diameter on the order of 100 nm were obtained with a curcumin recovery rate up to 87% compared to the conventional Soxhlet-assisted extraction in acetone. Their stability during the freeze-drying step has been studied in order to obtain a curcumin-loaded formulation easily stored and ready for use. Extremulsions did not show significant alteration in droplet size and composition after freeze-drying and rehydration.

Graphical abstract: One-pot solvent-free extraction and formulation of lipophilic natural products: from curcuma to dried formulations of curcumin

Supplementary files

Article information

Article type
Paper
Submitted
15 Feb 2021
Accepted
31 Aug 2021
First published
31 Aug 2021

Green Chem., 2021,23, 8891-8900

One-pot solvent-free extraction and formulation of lipophilic natural products: from curcuma to dried formulations of curcumin

A. Dall'armellina, M. Letan, C. Duval and C. Contino-Pépin, Green Chem., 2021, 23, 8891 DOI: 10.1039/D1GC00587A

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