Photoredox-catalyzed 2,2,2-trifluoroethylation and 2,2-difluoroethylation of alkenes with concomitant introduction of a quinoxalin-2(1H)-one moiety

Abstract

A photoredox-catalyzed strategy for difunctionalization of alkenes with readily available quinoxalin-2(1H)-ones and inexpensive ICH₂CF₃/ICH₂CF₂H was developed. This reaction proceeded under mild conditions, affording the corresponding three-component coupling products in moderate to high yields and excellent regioselectivity. It provides a new protocol to access valuable CF₃CH₂- and HCF₂CH₂-containing compounds.