Metal-free tandem carbene N–H insertions and C–C bond cleavages

Abstract

A metal-free C–H [5 + 1] annulation reaction of 2-arylanilines with diazo compounds has been achieved, giving rise to two types of prevalent phenanthridines via highly selective C–C cleavage. Compared to the simple N–H insertion manipulation of diazo, this method elegantly accomplishes a tandem N–H insertion/S_EAr/C–C cleavage/aromatization reaction, and the synthetic utility of this new transformation is exemplified by the succinct syntheses of trisphaeridine and bicolorine alkaloids.

---

Introduction

Carbene conversion represents one of the most fundamental and synthetically useful reactions in modern organic syntheses.¹ Of particular interest are diazo compounds, a class of “smart” carbene precursors that are being extensively utilized as versatile synthetic feedstock in the chemical as well as biological arena.² A myriad of synthetically significant applications of diazo compounds have been realized in Wolff rearrangements,³ cyclopropanations,⁴ ylide formations,⁵ X–H insertions,⁶ C–H functionalizations⁷ and so forth (Scheme 1a). Regarding these examples, it is well known that metal-carbenes play a pivotal role; namely, diazo chemistry mainly relies on metal catalysts (e.g. Rh, Ru, Pd, Ir, Ag, Cu and Co) for arriving at the carbenoid reactivity. On account of strict constraints imposed by trace levels of metals in pharmaceuticals and also reaction economy,⁸ however, this “metal-engaged” mode of reactivity dramatically overshadows the prospective applications of diazo chemistry. In striking contrast, the evolvement of metal-free technologies heavily lags behind, albeit several elegant yet sporadic reactions have emerged in recent years.⁹ Moreover, these studies commonly refer to a “one-fold” operation forming only a single chemical bond within the entire process.¹⁰ Against this background, the exploration of more synthetically innovative streamlined approaches and strategies through multiple bond breaking/forming events in the absence of transition metals, such as domino and cascade reactions of diazo compounds, would be a desirable goal. In this paper, we report a new platform for upgrading a transform of model diazo compounds through a Brønsted acid-promoted N–H insertion/S_EAr/C–C cleavage/oxidative aromatization four-fold domino reaction in a single chemical operation.

Scheme 1 Chemical reactivity of diazo and this work.

It is worth noting that N–H insertion/conversion is among the most promising platforms for constructing the ubiquitous C–N bonds widely encountered in an enormous number of bioactive molecules and countless top-selling marketed drugs, and this mode of reactivity has attracted significant endeavors in recent years and has been used to build numerous natural products.¹¹ To date, while impressive progress has been made in the systems capitalizing on metal catalysts,¹² there are only a handful of metal-free transformations between amines and diazo compounds¹³ (Scheme 1b). Pertinent work was done by Davies¹⁴ in 2012, wherein a thermolysis strategy enabled donor/acceptor carbenes to couple with amines. More recently, the groups of Davies¹⁵ and Jurberg¹⁶ demonstrated a blue LED-triggered N–H insertion reaction with amines and carbazoles, respectively. Notwithstanding the fundamental challenges in metal-free carbene insertions, these cases simply operated by N–H insertion and no further derivatization took place, which sharply hampered the formation of highly functionalized, structurally complex nitrogen-containing molecules, such as N-heterocycles. Indeed, these examples could be merely applied to more active, more nucleophilic, donor/acceptor carbenes. Within our recent strong interest in aniline chemistry,¹⁷ herein, we report an unprecedented Brønsted acid-promoted divergent [5 + 1] annulation between 2-arylanilines and acceptor/acceptor diazo carbenes in the absence of transition-metal catalysts (Scheme 1c), which fully differs from the precedent reaction versions between 2-arylanilines and diazo compounds mediated by metal catalysts (Scheme 1d). This newly established methodology performs a highly selective C–C bond cleavage with diazo compounds in a divergent, substrate-controlled mode, thus rapidly building two types of prevalent phenanthridine cores that are persistent in natural products and functional materials,¹⁸ but their de novo synthesis often requires intricate metal-catalyzed or light-promoted systems¹⁹ (Scheme 2).

Scheme 2 Biologically active phenanthridine derivatives and existing synthetic methods.

Scheme 3 Substrate scope of [5 + 1] annulation.

Scheme 4 Substrate scope of deacylative [5 + 1] annulation.

Results and discussion

At the outset, we executed this study by reacting 2-phenylaniline 1a with diazo compound 2a (Table 1). After investigating several reaction parameters, the desired phenanthridine 3a was obtained in 50% isolated yield in trifluoroacetic acid (TFA) at 100 °C under O₂ for 15 h (entry 1). Experimental results showed that employing TFA as the reaction solvent was vital, and other common solvents such as DMF, THF, HFIP, toluene, dioxane, and acetic acid were all absolutely futile, wherein only a certain amount of Wolff rearrangement product 6 was formed (entries 2–7). A decreased yield occurred when the reaction proceeded under air atmosphere; especially a nonaerobic system just resulted in 13% yield of 3a (entries 8–9), which undoubtedly clarified the significance of an aerobic environment. Changing the reaction temperature to either lower or higher levels diminished the efficiency (entries 10–11). When we turned our attention to phenyl-substituted substrate 2b, gratifyingly, the efficacy of the title transformation improved and yielded the target 3a in 65% yield (entry 12). Motivated by the above structure–activity relationship, we investigated the ester-modified diazo compound 2c in an attempt to further the optimization; unexpectedly, this procedure delivered exclusively another type of phenanthridine 4a in 37% yield (entry 13). In this method, phenyl-ester diazo compound 2d also behaved more efficiently and led to 76% yield (entry 14). Interestingly, persistency with diketo-derived diazo compound 2e failed to generate the corresponding 3a and 4a^II; however, the third chemoselective product 5 was furnished in 18% yield (entry 15). Apparently, this divergent outcome hinges upon the exact structure of the diazo precursor to construct structurally distinct phenanthridines.

Table 1 Optimization of reaction conditions

Entry	Variation from the assigned conditions	Yield^b (%)
		3a	4	5	6
a Assigned conditions: 1a (0.20 mmol), 2a (0.30 mmol), TFA (1.6 mL), 100 °C, 15 h, and O2 atmosphere. b Isolated yields (n.d: not detected).
1^a	None	50	4a^I/n.d	n.d	n.d
2	DMF + TFA(10.0 equiv.)	n.d	4a^I/n.d	n.d	14
3	THF + TFA(10.0 equiv.)	n.d	4a^I/n.d	n.d	33
4	HFIP + TFA(10.0 equiv.)	5	4a^I/n.d	n.d	6
5	Toluene + TFA(10.0 equiv.)	5	4a^I/n.d	n.d	35
6	Dioxane + TFA(10.0 equiv.)	n.d	4a^I/n.d	n.d	46
7	AcOH + TFA(10.0 equiv.)	n.d	4a^I/n.d	n.d	20
8	Air instead of O2	43	4a^I/n.d	n.d	n.d
9	N2 instead of O2	13	4a^I/n.d	n.d	n.d
10	80 °C instead of 100 °C	33	4a^I/n.d	n.d	n.d
11	120 °C instead of 100 °C	26	4a^I/n.d	n.d	n.d
12	2b instead of 2a	65	4a^I/n.d	n.d	n.d
13	2c instead of 2a	n.d	4a/37	n.d	n.d
14	2d instead of 2a	4	4a/76	n.d	n.d
15	2e instead of 2a	n.d	4a^II/n.d	18	n.d

---

Having identified the optimal reaction conditions, we firstly strived to test the substrate scope of this acid-induced [5 + 1] annulation reaction by choosing benzoyl-phenylsulfonyl diazo compound 2b as a synthetic partner. Overall, an extensive range of 2-arylanilines (1a–1q) participated in this predicted transformation quite well, furnishing the homologous phenanthridine products 3a–3q in 51–83% yields. With respect to either an ortho-arene system or an aniline segment, the substituted functionalities with different electronic groups including methyl (3b, 3k), methoxy (3c, 3e), phenyl (3d), methylenedioxy (3f), fluoro (3g), bromo (3h), chloro (3l), and trifluoromethyl (3m) were all compatible to undergo this protocol efficiently. As expected, the electron-deficient substrates behaved slightly less expediently. Gratifyingly, heterocyclic substrates such as thienyl (2i) and furyl (2j) were also efficient in this [5 + 1] annulation procedure. Notably, 2-arylanilines 2f–2i, possessing two potential C–H cyclization sites, preferentially operated at the least sterically congested position with excellent regioselectivity, except for the less selective performance with substrate 2e. More strikingly, the very useful π-extended phenanthridines widely found in functional materials, such as tetracycles (3n, 3p) and pentacycles (3o, 3q), were also efficiently obtained according to this highly selective [5 + 1] annulation in good yields.

Considering the distinct chemoselective behaviour with ester-derived diazo compound 2d (entry 14, Table 1), building highly functionalized 6-phenanthridines, we attempted to assess the generality of the deacylative [5 + 1] annulation process. Under the identified reaction conditions, reacting diazo 2d or 2f with a series of 2-arylanilines generated 6-carboalkoxy-phenanthridines (4a–o) in generally good yields. Notably, all the vacant carbons around the ortho-phenyl ring were applicable to introduce either electron-donating groups (4b–d and 4h–i), electron-withdrawing groups (4e–4g), or sterically encumbered phenanthrene scaffold (4j). The naphthylamine substrate 1n was amenable to this programed synthesis smoothly as well. Similar to the preceding desulfonylative/deacylative [5 + 1] annulation, this deacylative protocol generally showed slightly inferior results with electron-deficient substrates, although it is worth nothing that the appendage of bromo (4f) and ester (4g) groups could be valuable in downstream chemical transformations. Heterocyclic substrates 1v and 1i also allowed forming the corresponding products with excellent regioselectivity (>20 : 1). Meanwhile, the structure of 4m was unambiguously assigned by X-ray crystallographic analysis. It is noteworthy that the unprotected indole substrate 1w remained intact to produce the anticipated phenanthridine 4n in 55% yield. Further experimental results also showed that introducing other ester-carrying diazo compounds, such as 2f, was well supported, giving rise to the expected product 4o in 67% yield (Scheme 4).

In consideration of the capacity of this newly established method to rapidly assemble phenanthridines, we embarked on building trisphaeridine and other value-added derivatives constituting the core components of Amaryllidaceae alkaloids.²⁰ Much to our delight, 2-arylaniline 1f, which was derived directly from commercially available reagents via Suzuki coupling, strongly performed in the scaled-up transformation, yielding trisphaeridine molecule 3f in 75% isolated yield on a gram scale. More importantly, N-methylation of 3f produced phenanthridine salt 3f¹ and the subsequent anion exchange gave rise to bicolorine 3f², a natural product which was isolated from Narcissus bicolor and shows promising anticancer activity. Additionally, after reduction and carbonyl derivatization, two other alkaloids, dihydrobicolorine 3f³ and N-methylcrisanidine 3f⁴, were also prepared in good yields (Scheme 5).

Scheme 5 Synthetic application of established [5 + 1] annulation.

To investigate the reaction pathway, a set of preliminary experiments was conducted. As shown in Scheme 6, the values (K_H/K_D = 1.3 : 1 and 1.1 : 1) of kinetic isotope effects implied that S_EAr was not involved in the rate-determining step during this divergent [5 + 1] annulation process (Scheme 6a). Upon treatment with deuterated TFA, the experimental outcome suggested that the hydrogen from TFA participated in the product formation (Scheme 6b). With respect to the formation of phenanthridine 3a, the hypothetical electronically neutral secondary amine intermediate 7 was synthesized but failed to execute the envisioned cyclization. In contrast, the electron-deficient amine 8 delivered the product 3a, albeit in a lower yield of 25% (Scheme 6c), which revealed that an imine species might be engaged in the titular transformation and that the more electron-withdrawing substrate nature favors the reaction. Indeed, the prepared secondary ester-carrying amine 9 also led to the construction of phenanthridine 4a in 23% yield (Scheme 6d). Although our persistent attempts to synthesize other potential intermediates were frustrated, the above-outlined set of uniform experimental results indicated that an imine intermediate containing electron-deficient both R¹ and R² might enable this [5 + 1] protocol smoothly.

Scheme 6 Mechanistic studies. (a) Kinetic isotope effect experiments. (b) Deuterium-labeling experiments. (c) Investigating intermediate toward phenanthridine 3a. (d) Investigating intermediate toward phenanthridine 3a.

According to our mechanistic findings and literature precedents,²¹ the tentative reaction pathway for assembling the two classes of phenanthridines by divergent [5 + 1] annulation is proposed (Scheme 7). Under acidic conditions, the protonation of a diazo compound initially takes place to deliver species A, followed by N₂ extrusion^21a–c to produce secondary amine Bvia nucleophilic attack of NH_2. This key intermediate as verified undergoes oxidation and subsequently performs the S_EAr process, which is supported by the superior result of electron-rich 2-arylanilines in Schemes 3 and 4, to generate C–H functionalization product D. At this point, when the R unit consists of an ester group, selective C–C bond cleavage occurs via deacylation of the more electrophilic acyl group^21d,e and concomitant release of benzoic acid that was identified by NMR spectroscopy, followed by oxidative aromatization^21f,g to give product 4a. Comparatively, adjusting R to a more active SO₂Ph group promotes a successive de-sulfonylation/de-acylation/oxidative aromatization to finally furnish phenanthridine 3a.

Scheme 7 Proposed reaction pathway.

Conclusions

In conclusion, we have demonstrated a substrate-controlled selective [5 + 1] annulation reaction of 2-arylanilines with diazo compounds by a tandem N–H insertion/S_EAr/C–C cleavage/aromatization under metal-free conditions. Using sulfonyl-derived diazo compounds as the coupling partners, substituent-free phenanthridines are prepared by a dual desulfonylation and deacylation process. Alternatively, introducing ester-derived diazo compounds into the system divergently leads to the exclusive assembly of C6-carboalkoxy-substituted phenanthridines. Remarkably, the methodology has also been applied to a concise assembly of biologically active trisphaeridine and bicolorine Amaryllidaceae alkaloids as well as their derivatives. This study to the best of our knowledge represents the first example of Brønsted acid-promoted metal-free N–H insertion/multifold bond reorganization of diazo compounds. Metal-free domino transformations of diazo compounds will greatly expand the synthesis of omnipresent synthetic motifs.

Conflicts of interest

There are no conflicts to declare.

Acknowledgements

This work was financially supported by the NSFC (21801159), the China Post-doctoral Science Foundation (2018M640944), the Natural Science Basic Research Plan in Shaanxi Province of China (2020JQ-705), and the Education Department of Shaanxi Province (18JK0110).

Notes and references

1. (a) A. J. Arduengo and G. Bertrand, Chem. Rev., 2009, 109, 3209; (b) Y. Xia, D. Qiu and J. Wang, Chem. Rev., 2017, 117, 13810; (c) D. Zhu, L. Chen, H. Fan, Q. Yao and S. Zhu, Chem. Soc. Rev., 2020, 49, 908; (d) Z. Yang, M. L. Stivanin, I. D. Jurberg and R. M. Koenigs, Chem. Soc. Rev., 2020, 49, 6833.
2. (a) A. Homberg and J. Lacour, Chem. Sci., 2020, 11, 6362; (b) H. Kato, I. Musha, M. Komatsuda, K. Muto and J. Yamaguchi, Chem. Sci., 2020, 11, 8779; (c) Q. Zhang, Q. Xiong, M. Li, W. Xiong, B. Shi, Y. Lan, Q. Lu and W. Xiao, Angew. Chem., Int. Ed., 2020, 59, 14096; (d) A. Dasgupta, K. Stefkova, R. Babaahmdi, L. Gierlichs, A. Ariafard and R. L. Melen, Angew. Chem., Int. Ed., 2020, 59, 15492; (e) Y. Su, G. Liu, J. Liu, L. Tram, H. Qiu and M. P. Doyle, J. Am. Chem. Soc., 2020, 142, 13846.
3. For selected examples, see: (a) R. Sarpong, J. T. Su and B. M. Stoltz, J. Am. Chem. Soc., 2003, 125, 13624; (b) X. Hu, X. Chen, Y. Shao, H. Xie, Y. Deng, Z. Ke, H. Jiang and W. Zeng, ACS Catal., 2018, 8, 1308; (c) X. Hu, F. Chen, Y. Deng, H. Jiang and W. Zeng, Org. Lett., 2018, 20, 6140; (d) J. Liu, M. Li, B. Qu, L. Lu and W. Xiao, Chem. Commun., 2019, 55, 2031; (e) J. Meng, W. Ding and Z. Han, Org. Lett., 2019, 21, 9801.
4. For selected examples, see: (a) D. A. Vargas, R. L. Khade, Y. Zhang and R. Fasan, Angew. Chem., Int. Ed., 2019, 58, 10148; (b) B. Wang, I. G. Howard, J. W. Pope, E. D. Conte and Y. Deng, Chem. Sci., 2019, 10, 7958; (c) Z. Yang, M. Möller and R. M. Koenigs, Angew. Chem., Int. Ed., 2020, 59, 5572; (d) Z. Zhang, M. Zheng, X. Xue, I. Marek, F. Zhang and J. Ma, Angew. Chem., Int. Ed., 2019, 58, 18191; (e) K. L. Smith, C. L. Padgett, W. D. Mackay and J. S. Johnson, J. Am. Chem. Soc., 2020, 142, 6449.
5. For selected examples, see: (a) D. M. Hodgson, F. Y. T. M. Pierard and P. A. Stupple, Chem. Soc. Rev., 2001, 30, 50; (b) A. DeAngelis, M. T. Taylor and J. M. Fox, J. Am. Chem. Soc., 2009, 131, 1101.
6. For selected examples, see: (a) W. Chan, S. Lo, Z. Zhou and W. Yu, J. Am. Chem. Soc., 2012, 134, 13565; (b) Q. Zhou, S. Li, Y. Zhang and J. Wang, Angew. Chem., Int. Ed., 2017, 56, 16013; (c) Y. Jang, Ł. Woźniak, J. Pedroni and N. Cramer, Angew. Chem., Int. Ed., 2018, 57, 12901; (d) A. Olmos, R. Gava, B. Noverges, D. Bellezza, K. Jacob, M. Besora, W. M. C. Sameera, M. Etienne, F. Maseras, G. Asensio, A. Caballero and P. J. Pérez, Angew. Chem., Int. Ed., 2018, 57, 13848; (e) Z. Yu, Y. Li, P. Zhang, L. Liu and J. Zhang, Chem. Sci., 2019, 10, 6553.
7. For selected examples, see: (a) X. Li and D. P. Curran, J. Am. Chem. Soc., 2013, 135, 12076; (b) J. R. Jagannathan, J. C. Fettinger, J. T. Shaw and A. K. Franz, J. Am. Chem. Soc., 2020, 142, 11674; (c) Y. Li, Y. Zhao, T. Zhou, M. Chen, Y. Li, M. Huang, Z. Xu, S. Zhu and Q. Zhou, J. Am. Chem. Soc., 2020, 142, 10557.
8. (a) D. Nair, J. Scarpello, L. White, L. Freista dos Santos, I. Vankelecom and A. Livingston, Tetrahedron Lett., 2001, 42, 8219; (b) C. E. Garrett and K. Prasad, Adv. Synth. Catal., 2004, 346, 889.
9. (a) S. R. Ovalles, J. H. Hansen and H. M. L. Davies, Org. Lett., 2011, 13, 4284; (b) H. Lam, Z. Qureshi, M. Wegmann and M. Lautens, Angew. Chem., Int. Ed., 2018, 57, 16185; (c) A. Suneja and C. Schneider, Org. Lett., 2018, 20, 7576; (d) J. Ghorai and P. Anbarasan, Org. Lett., 2019, 21, 3431; (e) J. Ye, L. Quach, T. Paulisch and F. Glorius, J. Am. Chem. Soc., 2019, 141, 16227; (f) X. Yi, J. Feng, F. Huang and J. B. Baell, Chem. Commun., 2020, 56, 1243; (g) H. Zheng, K. Dong, D. Wherritt, H. Arman and M. P. Doyle, Angew. Chem., Int. Ed., 2020, 59, 13613; (h) N. Holmberg-Douglas, N. P. R. Onuska and D. A. Nicewicz, Angew. Chem., Int. Ed., 2020, 59, 7425; (i) K. Wu, L. Wu, C. Zhou and C. Che, Angew. Chem., Int. Ed., 2020, 59, 16202.
10. (a) J. Barluenga, M. Tomás-Gamasa, F. Aznar and C. Valdés, Angew. Chem., Int. Ed., 2010, 49, 4993; (b) C. Zhai, D. Xing, C. Jing, J. Zhou, C. Wang, D. Wang and W. Hu, Org. Lett., 2014, 16, 2934; (c) C. Tortoreto, D. Rackl and H. M. L. Davies, Org. Lett., 2017, 19, 770; (d) R. P. Pandit, S. T. Kim and D. H. Ryu, Angew. Chem., Int. Ed., 2019, 58, 13427; (e) R. D. C. Gallo, P. B. Momo, D. P. Day and A. C. B. Burtoloso, Org. Lett., 2020, 22, 2339; (f) N. Holmberg-Douglas, N. P. R. Onuska and D. A. Nicewicz, Angew. Chem., Int. Ed., 2020, 59, 7425; (g) Z. Li, J. Chen, L. Wu, A. Ren, P. Lu and Y. Wang, Org. Lett., 2020, 22, 26; (h) Z. Zhang, Y. Yu, F. Huang, X. Yi, Y. Xu, Y. He, J. B. Baell and H. Huang, Green Chem., 2020, 22, 1594.
11. (a) T. N. Salzmann, R. W. Ratcliffe, B. G. Christensen and F. A. Bouffard, J. Am. Chem. Soc., 1980, 102, 6161; (b) C. F. Garcia, M. A. McKervey and T. Ye, Chem. Commun., 1996, 1465; (c) M. C. Bagley, K. E. Bashford, C. L. Hesketh and C. J. Moody, J. Am. Chem. Soc., 2000, 122, 3301; (d) B. Xu, S. Zhu, X. Zuo, Z. Zhang and Q. Zhou, Angew. Chem., Int. Ed., 2014, 126, 3994; (e) K. Liu, C. Zhu, J. Min, S. Peng, G. Xu and J. Sun, Angew. Chem., Int. Ed., 2015, 54, 12962.
12. (a) A. C. B. Burtoloso, R. M. P. Dias and B. Bernardim, Acc. Chem. Res., 2015, 48, 921; (b) J. Yoo, N. Park, J. H. Park, J. H. Park, S. Kang, S. M. Lee, H. J. Kim, H. Jo, J. Park and S. U. Son, ACS Catal., 2015, 5, 350; (c) M. Li, J. Yu, Y. Li, S. Zhu and Q. Zhou, Science, 2019, 366, 990; (d) S. M. Bierschenk, R. G. Bergman, K. N. Raymond and F. D. Toste, J. Am. Chem. Soc., 2020, 142, 733.
13. (a) Z. J. Wang, N. E. Peck, H. Renata and F. H. Arnold, Chem. Sci., 2014, 5, 598; (b) G. Sreenilayam and R. Fasan, Chem. Commun., 2015, 51, 1532; (c) X. Xu, C. Li, Z. Tao and Y. Pan, Adv. Synth. Catal., 2015, 357, 3341.
14. S. R. Hansen, J. E. Spangler, J. H. Hansen and H. M. L. Davies, Org. Lett., 2012, 14, 4626.
15. I. D. Jurberg and H. M. L. Davies, Chem. Sci., 2018, 9, 5112.
16. M. L. Stivanin, A. A. G. Fernandes, A. F. daSilva, C. Y. Okada Jr and I. D. Jurberg, Adv. Synth. Catal., 2020, 362, 1106.
17. (a) J. Nan, Y. Hu, P. Chen and Y. Ma, Org. Lett., 2019, 21, 1984; (b) P. Chen, J. Nan, Y. Hu, Q. Ma and Y. Ma, Org. Lett., 2019, 21, 4812; (c) X. Wang, J. Zhang, Y. He, D. Chen, C. Wang, F. Yang, W. Wang, Y. Ma and M. Szostak, Org. Lett., 2020, 22, 5187.
18. (a) B. D. Krane, M. O. Fagbule, M. Shamma and B. Gozler, J. Nat. Prod., 1984, 47, 1; (b) S. Prado, S. Michel, F. Tillequin, M. Koch, B. Pfeiffer, A. Pierré, S. Léonce, P. Colson, B. Baldeyrou, A. Lansiaux and C. Bailly, Bioorg. Med. Chem., 2004, 12, 3943; (c) P. H. Bernardo, K. F. Wan, T. Sivaraman, J. Xu, F. K. Moore, A. W. Hung, H. Y. K. Mok, V. C. Yu and C. L. L. Chai, J. Med. Chem., 2008, 51, 6699; (d) Z. Luo, F. Wang, J. Zhang, X. Li, M. Zhang, X. Hao, Y. Xue, Y. Li, F. D. Horgen, G. Yao and Y. Zhang, J. Nat. Prod., 2012, 75, 2113.
19. (a) T. Gerfaud, L. Neuville and J. Zhu, Angew. Chem., Int. Ed., 2009, 48, 572; (b) D. A. Candito and M. Lautens, Angew. Chem., Int. Ed., 2009, 48, 6713; (c) Z. Liang, L. Ju, Y. Xie, L. Huang and Y. Zhang, Chem. – Eur. J., 2012, 18, 15816; (d) Y. Liu, R. Song, C. Wu, L. Gong, M. Hu, Z. Wang, Y. Xie and J. Li, Adv. Synth. Catal., 2012, 354, 347; (e) J. Liu, C. Fan, H. Yin, C. Qin, G. Zhang, X. Zhang, H. Yia and A. Lei, Chem. Commun., 2014, 50, 2145; (f) W. Chen, C. Chen, Y. Chen and J. Hsieh, Org. Lett., 2015, 17, 1613; (g) H. Jiang, X. An, K. Tong, T. Zheng, Y. Zhang and S. Yu, Angew. Chem., Int. Ed., 2015, 54, 4055; (h) J. Rong, L. Deng, P. Tan, C. Ni, Y. Gu and J. Hu, Angew. Chem., Int. Ed., 2016, 55, 2743; (i) Z. Wang, T. Li, J. Zhao, X. Shi, D. Jiao, H. Zheng and C. Chen, Org. Lett., 2018, 20, 6640; (j) D. Chowdhury, S. Dana, A. Mandal and M. Baidya, Chem. Commun., 2019, 55, 11908; (k) J. Fan, L. Li, J. Zhang and M. Xie, Chem. Commun., 2020, 56, 2775; (l) S. Liu, W. Pan, S. Wu, X. Bu, S. Xin, J. Yu, H. Xu and X. Yang, Green Chem., 2019, 21, 2905; (m) T. Xiao, L. Li, G. Lin, Q. Wang, P. Zhang, Z. Mao and L. Zhou, Green Chem., 2014, 16, 2421.
20. Z. Jin, Nat. Prod. Rep., 2013, 30, 849.
21. (a) N. Fei, B. Sauter and D. Gillingham, Chem. Commun., 2016, 52, 7501; (b) R. D. C. Gallo and A. C. B. Burtoloso, Green Chem., 2018, 20, 4547; (c) R. D. C. Gallo, P. B. Momo, D. P. Day and A. C. B. Burtoloso, Org. Lett., 2020, 22, 2339; (d) B. Li, B. Zhang, X. Zhang and X. Fan, Chem. Commun., 2017, 53, 1297; (e) X. Guo, J. Han, Y. Liu, M. Qin, X. Zhang and B. Chen, J. Org. Chem., 2017, 82, 11505; (f) Y. Huang, H. Song, Yu. Liu and Q. Wang, Chem. – Eur. J., 2018, 24, 2065; (g) P. Natarajan, D. Chuskita and Priya, Green Chem., 2019, 21, 4406.

---

Footnote

† Electronic supplementary information (ESI) available. CCDC 1954135. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/d0sc05763k

---