Issue 25, 2022
From the journal:

Chemical Communications

A smart probe for simultaneous imaging of the lipid/water microenvironment in atherosclerosis and fatty liver†

Zixuan Zhan, ORCID logo ‡a   Weihua Zhuang, ORCID logo ‡b   Qian Lei,a   Shufen Li, ORCID logo b   Wuyu Mao, ORCID logo *a   Mao Chen*b  and  Weimin Li*a  

* Corresponding authors

a Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Precision Medicine Key Laboratory of Sichuan Province & Precision Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
E-mail: wuyanmao1@sina.com

b Laboratory of Heart Valve Disease, Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China

Abstract

A smart lipid droplet specific fluorescent probe (LDs-DM) with dual-emission in water (706 nm) and oil (535 nm) under single-excitation was prepared for revealing the ultra-structure of the aqueous and lipidic microenvironment in living cells, fatty liver tissues and atherosclerotic plaques without fluorescence emission crosstalk. This work is expected to provide inspiration for designing a novel probe with color switching ability.

Graphical abstract: A smart probe for simultaneous imaging of the lipid/water microenvironment in atherosclerosis and fatty liver

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Article information

DOI
https://doi.org/10.1039/D2CC00795A
Article type
Communication
Submitted
08 Feb 2022
Accepted
23 Feb 2022
First published
23 Feb 2022

Chem. Commun., 2022,58, 4020-4023

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A smart probe for simultaneous imaging of the lipid/water microenvironment in atherosclerosis and fatty liver

Z. Zhan, W. Zhuang, Q. Lei, S. Li, W. Mao, M. Chen and W. Li, Chem. Commun., 2022, 58, 4020 DOI: 10.1039/D2CC00795A

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