Issue 2, 2022

Recent development in asymmetric organocatalytic domino reactions involving 1,6-addition as a key step

Abstract

Due to their unique activation modes, small organic molecule catalysts (organocatalysts) have proved their potential in facilitating the remote functionalizations of unsaturated acceptors with extended conjugation. The organocatalytic 1,6-addition reaction involving the attack of nucleophiles on the δ-carbon of the α,β,γ,δ-unsaturated acceptors has emerged as an excellent strategy to create a stereocenter at the δ-site with high regio- and stereo-control. Organocatalysis has also opened the window for developing complex domino reactions involving the 1,6-addition step. Tremendous advancement has been accomplished in the organocatalytic asymmetric 1,6-addition and related domino reactions for the stereocontrolled synthesis of complex molecular structures bearing multiple stereocenters. This review article summarizes the significant advancement in stereoselective domino reactions involving 1,6-addition as a critical step.

Graphical abstract: Recent development in asymmetric organocatalytic domino reactions involving 1,6-addition as a key step

Article information

Article type
Review Article
Submitted
18 Oct 2021
Accepted
13 Nov 2021
First published
15 Nov 2021

Org. Chem. Front., 2022,9, 572-592

Recent development in asymmetric organocatalytic domino reactions involving 1,6-addition as a key step

Y. Hussain, Tamanna, M. Sharma, A. Kumar and P. Chauhan, Org. Chem. Front., 2022, 9, 572 DOI: 10.1039/D1QO01561C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements