γ-Glutamyltranspeptidase and pH based “AND” logic gate fluorescent probe for orthotopic breast tumor imaging

Li-Na Zhang; Hong Zhang; Shan-Yong Chen; Yan-Zhao Liu; Xiao-Hua Yang; Fei-Fan Xiang; Yan-Hong Liu; Kun Li; Xiao-Qi Yu

doi:10.1039/D2CC06568A

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γ-Glutamyltranspeptidase and pH based “AND” logic gate fluorescent probe for orthotopic breast tumor imaging†

Li-Na Zhang,^a Hong Zhang,^a Shan-Yong Chen,

*^a Yan-Zhao Liu,^a Xiao-Hua Yang,^a Fei-Fan Xiang,^a Yan-Hong Liu,^a Kun Li

*^a and Xiao-Qi Yu

^ab

Author affiliations

* Corresponding authors

^a Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, China
E-mail: chensy@scu.edu.cn, kli@scu.edu.cn

^b Asymmetric Synthesis and Chiral Technology Key Laboratory of Sichuan Province, Department of Chemistry, Xihua University, Chengdu 610039, China

Abstract

An “AND” logic gate-based NIR fluorescent probe Si-NH₂-Glu was developed based on novel meso-amine Si-Rhodamine, which combined γ-glutamyl transpeptidase and pH dual-responsive sites. The features of Si-NH₂-Glu enable it to be applied in orthotopic tumor imaging and fluorescence-guided surgery.

This article is part of the themed collection: Chemosensors and Molecular Logic

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Article information

DOI: https://doi.org/10.1039/D2CC06568A
Article type: Communication
Submitted: 02 Dec 2022
Accepted: 07 Feb 2023
First published: 08 Feb 2023

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Chem. Commun., 2023,59, 2795-2798

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γ-Glutamyltranspeptidase and pH based “AND” logic gate fluorescent probe for orthotopic breast tumor imaging

L. Zhang, H. Zhang, S. Chen, Y. Liu, X. Yang, F. Xiang, Y. Liu, K. Li and X. Yu, Chem. Commun., 2023, 59, 2795 DOI: 10.1039/D2CC06568A

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Chemical Communications

γ-Glutamyltranspeptidase and pH based “AND” logic gate fluorescent probe for orthotopic breast tumor imaging†

Abstract

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γ-Glutamyltranspeptidase and pH based “AND” logic gate fluorescent probe for orthotopic breast tumor imaging

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