Issue 36, 2023

Electrochemical site-selective direct C–H sulfenylation and selenylation of a chromone-fused-indolizine (CFI) skeleton

Abstract

Herein, for the first time, we report the transition metal-free electrochemical site-selective direct C–H sulfenylation/selenylation of chromone-fused indolizine compounds (CFIs) to afford the corresponding CFIs thioethers and selenoethers   in 58–96% yields. The developed protocol offers a transition metal-free, ligand-free, catalyst-free methodology and is suitable for a variety of chalcogenide molecules (S and Se) along with various electron-rich and electron-poor chromone-fused indolizine compounds. Cyclic voltammograms and control experiments also validated the plausible reaction pathway.

Graphical abstract: Electrochemical site-selective direct C–H sulfenylation and selenylation of a chromone-fused-indolizine (CFI) skeleton

Supplementary files

Article information

Article type
Communication
Submitted
23 Feb 2023
Accepted
08 Apr 2023
First published
10 Apr 2023

Chem. Commun., 2023,59, 5415-5418

Electrochemical site-selective direct C–H sulfenylation and selenylation of a chromone-fused-indolizine (CFI) skeleton

P. K. Jat, L. Yadav, A. Chouhan, K. Ucheniya and S. S. Badsara, Chem. Commun., 2023, 59, 5415 DOI: 10.1039/D3CC00867C

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