Issue 36, 2023

A reactive oxygen species-responsive covalent organic framework for tumor combination therapy

Abstract

Herein, we report the first reactive oxygen species (ROS)-responsive dithioketal-linked covalent organic framework (COF) for synergetic chemotherapy and photodynamic therapy (PDT) of cancer. The singlet oxygen (1O2)-responsive COF dissociation and DC_AC50 drug release complement and reinforce each other to allow an efficient combination of PDT and chemotherapy.

Graphical abstract: A reactive oxygen species-responsive covalent organic framework for tumor combination therapy

Supplementary files

Article information

Article type
Communication
Submitted
07 Mar 2023
Accepted
12 Apr 2023
First published
12 Apr 2023

Chem. Commun., 2023,59, 5423-5426

A reactive oxygen species-responsive covalent organic framework for tumor combination therapy

W. Li, J. Kan, J. Wan, Y. Li, T. Song, B. Wang, Q. Guan, L. Zhou and Y. Dong, Chem. Commun., 2023, 59, 5423 DOI: 10.1039/D3CC01136D

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