Activatable BODIPY-chromene NIR-II probes with small spectral crosstalk enable high-contrast in vivo bioimaging

Liao Zhang; Chenxu Yan; Yutao Zhang; Dun Ma; Jialiang Huang; Zijun Zhao; Yining Tao; Caiqi Liu; Juan Li; Wei-Hong Zhu; Zhiqian Guo

doi:10.1039/D3CC01742G

Activatable BODIPY-chromene NIR-II probes with small spectral crosstalk enable high-contrast in vivo bioimaging†

Liao Zhang,^a Chenxu Yan,

^a Yutao Zhang,^a Dun Ma,^a Jialiang Huang,^a Zijun Zhao,^a Yining Tao,^a Caiqi Liu,^a Juan Li,^a Wei-Hong Zhu

^a and Zhiqian Guo

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science & Technology, Shanghai 200237, China
E-mail: guozq@ecust.edu.cn

Abstract

Herein, we design a novel “crossbreeding” dye (BC-OH) within the second near-infrared (NIR-II) window based on BODIPY and chromene chromophores. BC-OH can serve as a platform to construct activatable NIR-II probes with small spectral crosstalk, thereby making a breakthrough in imaging in vivo H₂O₂ fluctuation in an APAP-induced liver injury model with high signal-to-background ratio.

Chemical Communications

Activatable BODIPY-chromene NIR-II probes with small spectral crosstalk enable high-contrast in vivo bioimaging†

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Activatable BODIPY-chromene NIR-II probes with small spectral crosstalk enable high-contrast in vivo bioimaging

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