Issue 93, 2023

Self-assembly of alkylated lysine-dendron oxytocin amphiphiles for enhanced stability and sustained pharmacological activity

Abstract

Herein, we designed alkylated lysine-dendron oxytocin amphiphiles (ALOAs) 1G-OTK and 2G-OTK, which were self-assembled into spherical nanoparticles and nanostrips, respectively, and showed superior stability compared to native oxytocin. We found similar trends in the functional activity of ALOAs and native OT for human oxytocin receptor. This work may inspire the development of peptide drugs for clinical applications.

Graphical abstract: Self-assembly of alkylated lysine-dendron oxytocin amphiphiles for enhanced stability and sustained pharmacological activity

Supplementary files

Article information

Article type
Communication
Submitted
05 Aug 2023
Accepted
24 Oct 2023
First published
26 Oct 2023

Chem. Commun., 2023,59, 13855-13858

Self-assembly of alkylated lysine-dendron oxytocin amphiphiles for enhanced stability and sustained pharmacological activity

F. Xie, Y. Lin, Å. Andersson, I. Vetter, L. Zhao and J. Wan, Chem. Commun., 2023, 59, 13855 DOI: 10.1039/D3CC03801G

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