Hemanta
Deka§
ab,
Ida
Ritacco§
c,
Natalia
Fridman
a,
Lucia
Caporaso
*c and
Moris S.
Eisen
*a
aSchulich Faculty of Chemistry, Technion − Israel Institute of Technology, Technion City, Haifa, 3200003, Israel. E-mail: chmoris@technion.ac.il
bDepartment of Chemistry, Goalpara College, Goalpara, 783101, Assam, India
cDipartimento di Chimica e Biologia “Adolfo Zambelli”, Università degli Studi di Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Salerno, Italy
First published on 26th June 2023
Thorium complexes decorated with 5-, 6-, and 7-membered N-heterocyclic iminato ligands containing mesityl wingtip substitutions have been synthesized and fully characterized. These complexes were found to be efficient in the hydroboration of cyclic and linear organic carbonates with HBpin or 9-BBN promoting their decarbonylation and producing the corresponding boronated diols and methanol. In addition, the hydroboration of CO2 breaks the molecule into “CO” and “O” forming boronated methanol and pinBOBpin. Moreover, the demanding depolymerization of polycarbonates to the corresponding boronated diols and methanol opens the possibility of recycling polymers for energy sources. Increasing the core ring size of the ligands allows a better performance of the complexes. The reaction proceeds with high yields under mild reaction conditions, with low catalyst loading, and short reaction times, and shows a broad applicability scope. The reaction is achieved via the recycling of a high-energy Th–H moiety from a stable Th-OR motif. Experimental evidence and DFT calculations corroborate the formation of the thorium hydride species and the reduction of the carbonate with HBpin to the corresponding Bpin-protected alcohols and H3COBpin through the formate and acetal intermediates.
Due to the unique characteristics of the actinide metals, such as their large ionic radii and the presence of the 5f orbitals, large coordination numbers are achieved which influences them to display exceptional and complementary catalytic behaviors in comparison to early, late transition metals, and lanthanide complexes.11 A large number of literature publications have been disclosed in the last three decades regarding the catalytic activity of actinides, mainly uranium, and thorium, in various organic transformations like hydroborations, hydrosilylations, hydroaminations, polymerization of alkene and alkynes, and the ring-opening polymerization of lactones and lactides.12
During the last decade, our research interest has focused on the catalytic activity of organoactinides with N-heterocyclic iminato ligands. In a recent report, we disclose that the size of the core ring in Th(IV) complexes containing the N-heterocyclic iminato ligand greatly affects the catalytic activity of various reactions, mainly in the insertion of alcohols into carbodiimides.13 The 5-membered imidazolin-2-iminato complexes, [(ImDippN)Th{(N(SiMe3)2}3] is an excellent catalyst for the insertion of non-oxygenated species into various heterocumulenes, but the challenging insertion of oxygenated substances into carbodiimides remained infeasible.14 The use of the extended 6-membered pyrimidine core containing ligands forming the corresponding thorium complexes, (pyrimidineRN)Th{(N(SiMe3)2}3, were found highly active in the insertion of alcohols into carbodiimides.13 All 5- and 6-membered N-heterocyclic iminato ancillary ligands possess a nearly planar heterocyclic framework, and this feature generates constraints on the spatial arrangement of the wingtip substituents.7e,f,15
Hence, inspired by the recent advances in the hydroboration chemistry of actinides, we were intellectually driven to investigate the potential of a new set of thorium-based complexes, as catalysts, in the challenging reductive hydroboration of carbonates, cleaving the CO bridging unit towards methanol and diols. In this work, we decided to investigate a set of thorium complexes containing 5-, 6-, and 7-membered saturated iminato ligands. We have postulated that by using these coordinative unsaturated actinide-based complexes, the metal coordination sphere should be more available due to the release of their spatial constraint of the cyclic ring as compared to the actinide complexes based on iminato ligands with an aromatic planar cyclic core.15c–j
It has been already shown that an increase in the available metal coordination sphere for the substrates resulted in higher catalytic activities.15d The strategy that we wanted to pursue aimed towards the cleavage of the strong C–O bond of the carbonates by the electrophilic actinide metal complex. Moreover, regardless of the extremely strong actinide–oxygen bond, the recycling of the catalytic hydride from the alkoxo moiety was calculated to be exothermically plausible using HBpin (eqn (1)) and obtaining the concomitant B–O motif.16
(1) |
Fig. 1 Molecular structure of complexes Th-2, Th-3, and Th-4, with 50% thermal ellipsoid plot. All hydrogen atoms are omitted for clarity. |
The X-ray structural analysis of the complexes Th-2, Th-3, and Th-4 revealed that the central metal Th(IV) is in a distorted tetrahedral geometry. Its environment consists of one iminato ligand that binds monodentate fashion and three N-silylated amido (N{Si(CH3)3}2) groups.
Interestingly, the exocyclic N3–C1ipso bond distances are 1.273 (7), 1.304 (7), and 1.296 (7) Å for complexes Th-2, Th-3, and Th-4, respectively, and they are analogous to the corresponding bond lengths in the previously reported thorium-iminato complexes indicating that the mesomeric stabilization of the ligands has not a primordial influence.13
The Th–N3 bond distances in complexes Th-2, Th-3, and Th-4, 2.213 (5), 2.187 (5), and 2.220 (7) Å, respectively, are shorter than the corresponding Th–Namido bonds (average of 2.374 Å) indicating a high bond order between the iminato ligand and the metal center. The bond order is corroborated by the small bent Th–N3–C1 angles 168.0 (3)°, 162.7 (4)° and 171.1 (5)° for complexes Th-2, Th-3, and Th-4, respectively, allowing a substantial π-electron donation from the ligand to the metal.
We commenced the carbonate hydroboration studies, eqn (2) and (3), by initially examining the potential catalytic ability of the three complexes (Th-2, Th-3, and Th-4) (Table 1).
(2) |
(3) |
Entry | Substrate | Borane | Cat (mol%) | Time (h) | Yieldb (%) |
---|---|---|---|---|---|
a Reaction condition: carbonate (0.1 mmol), borane (0.33 mmol), precatalyst as marked at 80 °C in C6D6 (0.6 mL). b Yields of the boronated diol were determined by 1H NMR spectroscopy of the crude reaction mixture using mesitylene as internal standard. c The corresponding boronated formate ester is obtained. | |||||
1 | HBpin | Th-2 (0.1) | 4 | 52 | |
2 | HBpin | Th-3 (0.1) | 4 | 56 | |
3 | HBpin | Th-4 (0.1) | 4 | 65 | |
4 | HBpin | None | 48 | — | |
5 | 9-BBN | Th-4 (0.1) | 4 | 78 | |
6 | 9-BBN | None | 48 | 11c | |
7 | HBpin | Th-2 (0.1) | 12 | 31 | |
8 | HBpin | Th-3 (0.1) | 12 | 33 | |
9 | HBpin | Th-4 (0.1) | 12 | 45 | |
10 | HBpin | None | 12 | — | |
11 | 9-BBN | Th-4 (0.1) | 12 | 66 | |
12 | 9-BBN | None | 48 | — |
The complexes Th-2–Th-4 were studied as precatalysts for the hydroboration reaction of carbonates, polycarbonates, and carbon dioxide (vide infra) to form the corresponding borane-protected diols and methoxy borane. In all the reactions, the corresponding diols and methanol are obtained in quantitative yields from the reaction of the boronated ethers with HCl at room temperature for 1 h. To evaluate the catalytic efficiency of the various actinide complexes for the hydroboration of carbonates, initial exploratory experiments were carried out using ethylene carbonate (0.1 mmol), HBpin (0.33 mmol), and the precatalysts (0.001 mmol, 1 mol%) inside a J. Young Teflon valve-sealed NMR tube in C6D6. Under these conditions, 99% yield of the product for all the studied catalysts was observed at 80 °C. Hence, to identify the complex with the best catalytic activity, we reduced the catalyst loading to 0.1 mol%. Interestingly, all catalysts were found to be active giving related results, 52, 56, and 65% yield for complexes Th-2, Th-3, and Th-4, respectively, in 4 hours (entry 1–3, Table 1), indicating that complex Th-4 shows a slightly better reactivity than the other catalysts. Further optimization was performed by changing the substrate from acyclic to linear carbonate (entries 7–9, Table 1). The experiments were carried out for 12 h using diethyl carbonate (0.1 mmol), HBpin (0.33 mmol), and the Th precatalysts (0.1 mol%). The linear carbonates reacted slower as compared to the cyclic carbonates, and the highest reactivity was found to be 45% (entry 9, Table 1) obtained as before for complex Th-4. It is important to mention that all catalysts gave 100% conversion within 1 hour with 1 mol% catalyst loading. Moreover, no product was observed without a catalyst even after 48 hours of using HBpin (entries 4 and 10, Table 1). The activity of the thorium complexes for the carbonate hydroboration was also examined in the presence of other hydroboranes, such as catecholborane (HBcat) and 9-borabicyclo(3.3.1) nonane (9-BBN). The reaction of ethylene carbonate (0.1 mmol) and 9-BBN (0.33 mmol) in the presence of 0.1 mol% Th-4 yielded 78% of products after 4 hours (entry 5, Table 1), and only 11% conversion was obtained in 48 hours in the absence of the actinide catalyst (entry 6, Table 1). 9-BBN was also tested in the reaction with linear diethyl carbonate in the same manner as ethylene carbonate and the conversion was found to be 66% using complex Th-4 (entry 11, Table 1) and no product was obtained without a catalyst (entry 12, Table 1). The desired product formation was not observed using catechol borane.
Hence, we continue to explore the catalytic activity scope of complex Th-4 on the hydroboration of a variety of substrates under the optimized reaction conditions (Table 2). Assorted substituted cyclic carbonates were efficiently reduced to H3COBpin and the corresponding diol derivatives. Methyl, chloromethyl, hydroxymethyl, and phenyl-substituted ethylene carbonates were efficiently reduced to Bpin-protected diols and H3COBpin with excellent yields within 1 hour (entries 1c, 1d, 1e, and 1f, Table 2). Cyclohexene carbonate was also reduced within 1 hour to form the corresponding product (entry 1g, Table 2). Chemoselective reduction of unsaturated carbonates like 4-vinyl-1,3-dioxolan-2-one was also possible with HBpin without the reduction of the CC double bond (entry 1h, Table 2).
Six-membered ring organic carbonates also underwent efficient hydroboration, affording the corresponding 1,3-diol derivatives (entry 1i, Table 2). Linear carbonates require normally relatively harsh conditions as compared to cyclic carbonates, however, the simplest dimethyl carbonate was efficiently reduced to H3COBPin in 1 hour (entry 1j, Table 2). Interestingly, additional reaction time was required to reduce long-chain carbonates (entry 1k and 1l, Table 2). Diallyl carbonate and dibenzyl carbonate take even longer times to reduce to the corresponding alcohol derivatives and H3COBpin (entry 1m and 1n, Table 2). An asymmetrical organic carbonate like ethyl methyl carbonate was reduced effectively within 1 hour and formed EtOBpin and 2 equiv. of H3COBpin (entry 1o, Table 2). Diphenyl carbonate (entry 1p, Table 2) reacted slower and 24 h was needed to reach a quantitative conversion, whereas, for the substituted 2-methoxy diphenyl carbonate (entry 1q, Table 2), only 50% yield was obtained in 24 h. The substrate bis(pentafluorophenyl) carbonate was found to be inactive in this reaction with all the studied catalysts (entry 1r, Table 2). Further exploration was focused on the depolymerization of polycarbonates. Polypropylene carbonate which can be made from propylene oxide and CO2 smoothly underwent hydroboration in the presence of the 1 mol% of complex Th-4 in 48 hours (entry 1s, Table 2). Similarly, polybisphenol-A underwent efficient hydroboration to form its boronate monomer and H3COBpin under the same reaction conditions as other carbonates (entry 1t, Table 2).
The high catalytic activity of the complex Th-4 in the formation of methyl boronate from various carbonates prompted us to investigate its ability to reduce carbon dioxide directly under the same conditions. The reduction of CO2 to methanol or a methanol equivalent is an important field of current research interest as it provides strategies to utilize waste carbon dioxide as a chemical feedstock.18 The hydroboration of CO2 has been explored in this context using noble and non-noble transition metal catalysts.19 Guan et al. reported the first hydroboration of CO2 with catechol borane in 2010 to yield boronated methanol using a nickel pincer complex.19c Recently Leitner and co-workers reported the hydroboration of CO2 to its methanol derivative were a manganese(I) pincer complex act as a catalyst in the presence of a base.8 Up until now there is no report for the hydroboration of CO2 actinide-based catalysts.
Interestingly, complex Th-4 is able to catalyze the formation of boronated methanol using carbon dioxide as a feedstock under rather mild conditions, similar to those applied for the other carbonate substrates. Initial experiments were carried out in a J. Young Teflon valve-sealed NMR tube filled with 0.001 mmol of complex Th-4, 0.1 mmol pinacolborane, and 0.6 mL of benzene-d6. The NMR tube was connected to a standard Schlenk line equipped with a CO2 source and was allowed to react under ambient pressure at 80 °C for 48 hours. The presence of the boronated methanol in the solution was verified by NMR spectroscopy, yielding 99% based on the HBpin employed (entry 1u, Table 2). The reaction occurs with high selectivity and no other C1 compounds such as formaldehyde derivatives, CO, or methane were observed.
Rate = k[Th-4]1[ethylene carbonate]0[HBpin]1 | (4) |
The reaction was found to proceed with a first-order dependence on the complex Th-4 and HBpin concentrations and zero-order dependence on the carbonate concentration. The thermodynamic activation parameters consisting of relatively small and positive enthalpy of activation ΔH‡ = 12.8 ± 0.9 kcal mol−1 (Ea = 13.4 ± 0.9 kcal mol−1) and extremely large and negative entropy of activation ΔS‡ = −32.1 ± 0.9 e.u., suggesting an organized transition state during the rate-determining step.7d–f Comparison rate studies using both, the deuterated DBpin and HBpin yielded a kinetic isotope effect (KIE) of 3.08 ± 0.01, indicating that the cleavage of the B–H/D bond is involved at the rate-determining step (see ESI‡ for details on the kinetic measurement).
To gain more insights into the reaction mechanism, stoichiometric reactions of the catalyst with HBpin were carried out. No reaction was observed between the complex Th-4 and 4 equivalents of HBpin at room temperature even after 5 hours (see ESI, Fig. S66‡). When the same reaction mixture was heated at 80 °C for 1 hour, two distinct signals around 1.57 and 1.38 ppm of equal intensity in the 1H NMR appeared, which correspond to the ring-opening of HBpin and deactivates the catalyst by forming complex A (eqn (5)). The 11B NMR confirms the formation of A, which corroborates the report of Marks and coworkers in the reaction of lanthanum catalyzed ester and amide hydroboration.20
(5) |
The appearance of pinB-N(SiMe3)2 in the 1H NMR spectra of the stoichiometric reaction (δ = 1.03 and 0.37 ppm) and the 11B NMR spectra (δ 25.7 ppm) indicates that the hydroboronolysis of the Th–N(SiMe3)2 occurs. This reaction mixture was found to be almost inactive for further catalytic reactions (see ESI, Fig. S67–S69‡). In the catalytic reaction of HBpin, dimethyl carbonate, and complex Th-4, a signal at δ 25.7 ppm in the 11B NMR indicates the formation of pinB-N(SiMe3)2. In addition, a doublet at δ 34.2–33.2 ppm in the 1H coupled 11B NMR, which becomes a singlet in the 1H decoupled 11B NMR, indicates the formation of a coordinated HBpin in the active catalyst (see ESI, Fig. S70‡). The absence of the signal at −6.3 ppm in the 11B NMR indicates that the catalyst deactivation product A was not formed during the catalytic reaction.
In the previous reports of hydroboration of carbonyl7e compounds and nitrile,7g a thorium hydride species was reported, which initiates the catalytic cycle. Hydroboration of carbonates is also believed to proceed via a thorium hydride intermediate. But the reaction of an equimolar amount of Th-4 and HBPin at 60 °C also results in the formation of A and the rest of Th-4 was found unreacted (Fig. S68‡).
For further investigation of the reaction mechanism, several additional control experiments were carried out. Addition of 1 equivalent of HBpin to trimethylene carbonate in the presence of 1 mol% of complex Th-4 forms only the corresponding formate as the first intermediate (eqn (6)) (see ESI Fig. S73‡).
(6) |
1H NMR spectra of the catalytic reaction of trimethylene carbonate and 4.2 equivalents of HBpin catalyzed by complex Th-4 as a function of time are shown in Fig. 2. Fig. 2 shows that after the formation of the formate, the corresponding acetal is formed (signal at 7.6 ppm (a) and 5.0 ppm (a1), for the formate and acetal, respectively). The equivalent integration of the signals a1 and d1 confirms the formation of the acetal intermediate. The signals at a, a1, and a2 disappeared when the reaction was performed with DBpin instead of HBpin (see ESI Fig. S75‡).
These results clearly indicate that the HBpin first reacts with the complex activating it, then the carbonate and the second equivalent of HBpin reacts with the activated species forming the corresponding formate intermediate that subsequently reacts with another equivalent of HBpin to form the acetal intermediate. The last equivalent of HBpin reacts with the acetal to form the corresponding boronated diol and H3COBpin (eqn (6)). When the reaction with methyl formate was carried out with complex Th-4 and only 3 equiv. of HBpin (eqn (7)) the reaction proceeds rapidly forming two equiv. of boronated methanol. Important to mention that without complex Th-4 the reaction does not generate any product. Finally, when an equimolar mixture of dimethyl carbonate and methyl formate were reacted with HBpin and complex Th-4, the methyl formate was reduced quantitatively, whereas the carbonate remained unreacted (eqn (8)) indicating that methyl formate reacts much faster than the opening of the dimethyl carbonate or the boronated formate obtained in the equimolar reaction of trimethylene carbonate and HBpin (eqn (6)).
(7) |
(8) |
Starting from the activation mechanism, several pathways were theoretically considered (see ESI‡) according to the experimental evidence indicating that: (i) the precatalyst Th-4, the HBpin, and carbonate are essential for the activity; (ii) the formation of the hydride Th-4-H active species requires the metathesis reaction of HBpin with the Th–N* bond of Th-4 with the releasing of the pinB-N(SiMe3)2 species. However, all studied pathways involving the carbonate in the formation of the active hydride complex Th-4-H species were ruled out for the high energy barriers entailed (see ESI‡). Hence, the direct reaction of HBpin with complex Th-4 to form Th-4-H active species was considered.
In Scheme 3 the activation path is reported with the relative Gibbs energy (ΔG kcal mol−1, in benzene as solvent) calculated from complex Th-4 and HBpin at a distance infinite. The metathesis reaction of HBpin with the Th–N* bond requires the overcoming of an energy barrier of 27.0 kcal mol−1 to produce the corresponding hydride Th-4-H as the active species and pinB-N(SiMe3)2 that are in equilibrium (being at only −1.9 kcal mol−1 from the zero energy) with Th-4 and HBpin reactants. The geometry of the Act-TS1 is reported in Fig. 3.
Since experimentally in the absence of carbonate at 80 °C the complex Th-4 reacts with 4 equivalents of HBpin producing the inactive catalytic species A and pinB-N(SiMe3)2 (eqn (5)), the deactivation reaction mechanism was also studied starting from Th-4-H species (the activation product of the reaction between the first HBpin molecule and complex Th-4) set as zero energy.
As shown in Scheme 4, the deactivation reaction proceeds by the insertion of the second HBpin molecule into the Th-4-H bond through a TS (Deact-TS-1) at 1.9 kcal mol−1 that evolves directly and barrierless to the Deact-1 intermediate, at −10.6 kcal mol−1 from the zero, following the interaction of the HBpin oxygen with the metal and the subsequent opening of the cycle. By the metathesis reaction of the third HBpin molecule with the Th–N* bond, the deactivation product Deact-2, at −37.6 kcal mol−1, forms through an energy barrier of 26.6 kcal mol−1 (energy difference between Deact-1 at −10.6 kcal mol−1 and Deact-TS-2 at 16.0 kcal mol−1). Finally, the Deact-2 product, interacting with the fourth HBpin molecule, is in equilibrium with the deactivation product A in agreement with the experiments.
Moreover, calculations suggest that once Th-4-H forms, it reacts with HBpin molecules to form the more stable A product (at −34.5 kcal mol−1) through a similar energy barrier to the activation reaction (compare 27.0 kcal mol−1 with 26.6 kcal mol−1), which could explain why Th-4-H has not been isolated and detected experimentally.
In the presence of ethylene carbonate, once the hydride complex Th-4-H forms, the coordination of the carbonyl oxygen to the thorium occurs and readily evolves, through a barrierless transition state TS-E (see Scheme 5) at 0.1 kcal mol−1, to the kinetic product E-1 at −33.6 kcal mol−1 that barrierless generates a stable thorium alkoxide thermodynamic product E-2 at −41.9 kcal mol−1 shifting to the right the equilibrium Th-4 + HBpin ⇆ Th-4-H + pinB-N* (see Scheme 3).
By comparing the two reactions involving the complex Th-4-H (Schemes 4 and 5), the calculations clearly show that the reaction of Th-4-H with the carbonate is thermodynamically and kinetically favored than the competitive reaction with HBpin showing a lower energy barrier (of about 2 kcal mol−1) and a reaction product of ∼23 kcal mol−1 more stable (compare the energies of Deact-1 with E-1). These results are in agreement with the experimental observations and clearly indicate that the carbonate is essential in the reaction mixture to start the catalytic cycle and to avoid the deactivation of the catalyst which otherwise occurs with only HBpin.
Now, a metathesis reaction involving the Th–O bond of complex E-2 and an H–B σ-bond of a second HBpin molecule occurs via the TS-F overcoming an energy barrier of about 14 kcal mol−1 (See Scheme 6). The obtained F intermediate being at −41.2 kcal mol−1 is in equilibrium with E-2 (ΔΔG is about 0.7 kcal mol−1) and shows the complex Th-4-H interacting with the intermediate formate product pinBOROC(O)H. This is again in line with the experiments showing that the reaction of 1 equivalent of HBpin with complex Th-4-H in the presence of carbonate produces the corresponding formate as a reaction intermediate. The following reaction between the thorium hydride with the CO moiety of pinBOROC(O)H produces the stable alkoxide complex G at −66.9 kcal mol−1 which shifts the equilibrium towards the products. The TS involved in this step is at 19.3 kcal mol−1 from intermediate F.
Scheme 6 DFT calculations for the formation of the formate intermediate and its insertion with the thorium-hydride in the hydroboration of diethylene carbonate with HBpin catalyzed by complex Th-4. |
From G, and in analogy with the E-2 to F step, a metathesis reaction involving the alkoxide Th–O bond of G and the H–B bond of an additional HBpin occurs with the formation of the acetal intermediate H, consisting of the hydride Th-4-H interacting with pinBOROCH2OBpin, at −60.2 kcal mol−1, that is at ∼7 kcal mol−1 from the minimum G (see black line in Fig. 4 and Scheme 7). This is in agreement with the experimental results of the reaction of trimethylene carbonate in the presence of complex Th-4 and 3 equivalents of HBpin producing the corresponding acetal species.
Fig. 4 Competitive computed reaction pathways from intermediate G to Th-4-H passing from TS-H (black line) and TS-H′ (green line). The energy values are ΔG in kcal mol−1 in benzene. |
As a closing of the catalytic cycle, we initially assumed that pinBOROCH2OBpin and the Th-4-H complex react to form the H3COBpin product and a stable intermediate I (at −37.6 kcal mol−1 from G), which in turn, reacting with a fourth HBpin, forms the diol boronate product pinBOROBpin by regenerating the hydride active species Th-4-H. However, this pathway was excluded because it involves an energy barrier of 57.5 kcal mol−1 in the last step (see TS-I in Fig. 4).
Hence, alternative pathways starting from the minimum G to form H3COBpin and the boronated diol pinBOROBpin were considered (See Scheme 8).
In a calculated competitive pathway (see green line in Fig. 4 and Scheme 8), the third HBpin molecule reacts with complex G forming the thorium methoxide intermediate H′ with the formation of the boronated diol pinBOROBpin through the transition state TS-H′ at −33.7 kcal mol−1. This is a metathesis reaction involving one C–O bond of G and the H–B bond of the pinacol-borane assisted by the metal (see Fig. 5).
The cycle ends with the rapid metathesis reaction between the fourth molecule of HBpin and the intermediate thorium methoxide with the formation of the H3COBpin product and the regeneration of the active species Th-4-H.
As in Fig. 4 (green line), this pathway shows the highest energy barrier of 33.2 kcal mol−1, (from G to TS-H′) which is about 24 kcal mol−1 lower than the energy barrier from G to TS-I (see black line). This barrier is in acceptable agreement with the activation parameters reported in the experimental section. In addition, this step is the rate-determining one of the catalytic hydroboration and corroborates the experimental rate law above presented showing that only the thorium complex and the HBPin are involved. It is worth noting that this competitive pathway doesn't involve the formation of the pinBOROCH2OBpin intermediate that incidentally is experimentally observed only in the controlled reaction of complex Th-4 with 4 equivalents of HBpin.
In other words: from G, in the absence of a fourth HBpin molecule, the formation of pinBOROCH2OBpin is expected as H is kinetically favored over H′ (see black and green line in Fig. 4), in agreement with the corresponding experimental stoichiometric reaction. However, once a subsequent HBpin molecule is added, the reaction from H is hindered by the very high TS-I barrier. As a result, the reaction is reversed, and from G it switches to the thermodynamically favored intermediate H′ which allows the formation of the product pinBOROBpin (see green line in Fig. 4), in agreement with experiments.
Scheme 9 A plausible mechanism for the hydroboration of carbonates with HBpin catalyzed by complex Th-4. |
The reaction of the acetal intermediate with the thorium hydride Th-4-H releases the boronated H3COBpin and forms the Th-alkoxo intermediate I. σ-bond metathesis of I with another equivalent of HBpin releases the boronated diol as the final product and regenerates the hydride complex Th-4-H, which continues the catalytic cycle.
In the additional pathway (Path 2), complex G can react with HBpin to form the Th-methoxide intermediate releasing the boronated diol. σ-bond metathesis of the Th-methoxide with HBpin forms H3COBpin along with the regeneration of the hydride complex Th-4-H. When comparing the two pathways in Fig. 4, it emerges that the intermediate H, that is complex Th-4-H interacting with pinBOROCH2OBpin, is kinetically favored of 20.8 kcal mol−1 than intermediate H′ + pinBOROBpin that, conversely, is thermodynamically favored of 33.5 kcal mol−1. Therefore, when G and HBpin react, the intermediate H it forms because is kinetically favored and because the subsequent reaction is prevented by an energy barrier greater than 60 kcal mol−1. Conversely, if other HBpin molecules are available, the reaction proceeds through the formation of the thermodynamic product H′ along the green line (See Fig. 4), in agreement with the experiments showing the formation of the intermediate pinBOROCH2OBpin in the controlled reaction of complex Th-4 with 4 equivalents of HBpin and the formation of the products H3COBpin and pinBOROBpin.
Footnotes |
† Dedicated to Professor Ilan Marek on the occasion of his 60th birthday. |
‡ Electronic supplementary information (ESI) available: X-ray data of complexes, and experimental details for each product. Kinetics and thermodynamic details including KIE. Stoichiometric experiments and XYZ coordinates. CCDC 2226510–2226512. For ESI and crystallographic data in CIF or other electronic format see DOI: https://doi.org/10.1039/d3sc01700a |
§ These authors contributed equally. |
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