Issue 7, 2024

A microneedle patch realizes weight loss through photothermal induction of fat browning

Abstract

As a globally prevalent disease, obesity leads to many chronic diseases, so it is important to develop safe and effective treatments with fewer side effects and lasting weight loss. In this study, we developed a biodegradable hyaluronic acid microneedle patch loaded with polydopamine nanoparticles and mirabegron, which directly acted on subcutaneous white adipose tissue, and then induced browning of white adipose tissue through mild photothermal therapy. The approach showed excellent browning-promoting ability and biocompatibility. It is noteworthy that the weight of untreated mice increased by 9%, while the weight of obese mice decreased by nearly 19% after photothermal treatment. In addition, when mirabegron was used in combination with photothermal therapy, the weight loss of obese mice was more significant, with a weight loss of about 22%. This microneedle patch exhibited attractive potential for body slimming.

Graphical abstract: A microneedle patch realizes weight loss through photothermal induction of fat browning

Supplementary files

Article information

Article type
Paper
Submitted
30 Oct 2023
Accepted
06 Feb 2024
First published
07 Feb 2024

Biomater. Sci., 2024,12, 1726-1737

A microneedle patch realizes weight loss through photothermal induction of fat browning

Z. Gao, Y. Liu, W. Lin, H. Lian and Z. Meng, Biomater. Sci., 2024, 12, 1726 DOI: 10.1039/D3BM01767B

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