Issue 40, 2024

Electrochemical dual oxidative C(sp3)–H amination: switchable synthesis of imidazo-fused quinazolinones

Abstract

An efficient electrochemical dual C(sp3)–H amination was developed under metal-free and chemical oxidant-free conditions. A series of imidazo[1,5-a]quinazolin-5(4H)-ones and 5-oxo-4,5-dihydroimidazo[1,5-a]quinazoline-3-carbonitriles can be obtained in high yields and the product distribution can be modulated by virtue of this method. The reaction mechanism was investigated and the corresponding intermediates were studied. The reaction features a broad substrate scope, regulation of the product distribution, mild conditions and scalable preparation.

Graphical abstract: Electrochemical dual oxidative C(sp3)–H amination: switchable synthesis of imidazo-fused quinazolinones

Supplementary files

Article information

Article type
Communication
Submitted
01 Mar 2024
Accepted
28 Mar 2024
First published
01 Apr 2024

Chem. Commun., 2024,60, 5274-5277

Electrochemical dual oxidative C(sp3)–H amination: switchable synthesis of imidazo-fused quinazolinones

C. Du, Y. Zhang, T. Li, Z. Zha and Z. Wang, Chem. Commun., 2024, 60, 5274 DOI: 10.1039/D4CC00994K

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