Issue 54, 2024

Light-induced β-hydroxy sulfone synthesis in DNA-encoded libraries

Abstract

We here describe a visible-light photooxidation of sulfinate salts with common alkenes to yield β-hydroxy sulfones on DNA. This process demonstrates a broad substrate compatibility and achieves conversion rates ranging from moderate to excellent. Most importantly, it presents a straightforward, efficient, and metal-free approach for synthesizing Csp3-rich DNA-encoded libraries.

Graphical abstract: Light-induced β-hydroxy sulfone synthesis in DNA-encoded libraries

Supplementary files

Article information

Article type
Communication
Submitted
06 May 2024
Accepted
10 Jun 2024
First published
18 Jun 2024

Chem. Commun., 2024,60, 6885-6888

Light-induced β-hydroxy sulfone synthesis in DNA-encoded libraries

L. Xue, J. Yu, Y. Zhong, J. Chen, C. Li, K. Yang, N. Duchemin and Y. J. Hu, Chem. Commun., 2024, 60, 6885 DOI: 10.1039/D4CC02193B

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