Issue 71, 2024

Electrochemical biosensors for clinical detection of bacterial pathogens: advances, applications, and challenges

Abstract

Bacterial pathogens are responsible for a variety of human diseases, necessitating their prompt detection for effective diagnosis and treatment of infectious diseases. Over recent years, electrochemical methods have gained significant attention owing to their exceptional sensitivity and rapidity. This review outlines the current landscape of electrochemical biosensors employed in clinical diagnostics for the detection of bacterial pathogens. We categorize these biosensors into four types: amperometry, potentiometry, electrochemical impedance spectroscopy, and conductometry, targeting various bacterial components, including toxins, virulence factors, metabolic activity, and events related to bacterial adhesion and invasion. We discuss the merits and challenges associated with electrochemical methods, underscoring their rapid response, high sensitivity, and specificity, while acknowledging the necessity for skilled operators and potential interference from biological and environmental factors. Furthermore, we examine future prospects and potential applications of electrochemical biosensors in clinical diagnostics. While electrochemical biosensors offer a promising avenue for detecting bacterial pathogens, further research in optimizing the robustness and surmounting the challenges hindering their seamless integration into clinical practice is imperative.

Graphical abstract: Electrochemical biosensors for clinical detection of bacterial pathogens: advances, applications, and challenges

Article information

Article type
Feature Article
Submitted
10 May 2024
Accepted
25 Jul 2024
First published
09 Aug 2024

Chem. Commun., 2024,60, 9513-9525

Electrochemical biosensors for clinical detection of bacterial pathogens: advances, applications, and challenges

S. Ding, X. Chen, B. Yu and Z. Liu, Chem. Commun., 2024, 60, 9513 DOI: 10.1039/D4CC02272F

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