Issue 88, 2024
From the journal:

Chemical Communications

Target-assisted self-cleavage DNAzyme electrochemical biosensor for MicroRNA detection with signal amplification†

Juan Zhang, ORCID logo a   Benting Xie,a   Haonan He,a   Hejun Gao, ORCID logo a   Fang Liao,*a   Hongquan Fu ORCID logo *a  and  Yunwen Liao ORCID logo a  

* Corresponding authors

a College of Chemistry and Chemical Engineering, Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, Institute of Applied Chemistry, China West Normal University, Nanchong, Sichuan 637000, China
E-mail: liaofang407@163.com, fubestone@163.com

Abstract

In this work, we reported an electrochemical biosensor with target-assisted self-cleavage DNAzyme function for signal amplified detection of miRNA. The target-recycling amplification led to significant signal enhancement and thus offers high detection sensitivity.

Graphical abstract: Target-assisted self-cleavage DNAzyme electrochemical biosensor for MicroRNA detection with signal amplification

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Article information

DOI
https://doi.org/10.1039/D4CC04190A
Article type
Communication
Submitted
17 Aug 2024
Accepted
08 Oct 2024
First published
11 Oct 2024

Chem. Commun., 2024,60, 12904-12907

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Target-assisted self-cleavage DNAzyme electrochemical biosensor for MicroRNA detection with signal amplification

J. Zhang, B. Xie, H. He, H. Gao, F. Liao, H. Fu and Y. Liao, Chem. Commun., 2024, 60, 12904 DOI: 10.1039/D4CC04190A

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