Issue 13, 2024

Electrosynthesis of N/S-heterocycles

Abstract

The electrochemical generation of highly active and variable free radicals for the synthesis of organic compounds has emerged as a favored approach due to its mild and environmentally friendly characteristics, in contrast to traditional chemical redox reagents. As such, electrochemistry has been extensively applied in a wide range of synthetic transformations for the construction and functionalization of N/S-heterocycles in recent years. In this review, we present a comprehensive overview of our recent advancements in the methodology of electrochemically assisted radical generation and its subsequent application in the synthesis and functionalization of diverse N/S-heterocyclic compounds. In practice, we have developed various methodologies for the functionalization of N/S-heterocyclic compounds, including thiocyanation, alkylation, sulfonation, hydrogenation, pyridination, and the synthesis of complex N/S-containing heterocyclic compounds from readily available starting materials in an undivided cell. The methodology and mechanism of electrochemically mediated synthesis and functionalization of N/S-heterocycles will be discussed in terms of direct anodic oxidation, indirect oxidation, cathodic reduction, and paired electrolysis.

Graphical abstract: Electrosynthesis of N/S-heterocycles

Article information

Article type
Critical Review
Submitted
02 Apr 2024
Accepted
23 May 2024
First published
24 May 2024

Green Chem., 2024,26, 7532-7551

Electrosynthesis of N/S-heterocycles

J. Wen, Y. Yin, K. Yan, B. Li, M. Zhang and J. Yang, Green Chem., 2024, 26, 7532 DOI: 10.1039/D4GC01595A

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