Uniform and size-tunable dasatinib nanoemulsions synthesized by a high-throughput microreactor for enhanced temperature stability

Abstract

This study introduces a high-throughput microreactor for preparing dasatinib nanoemulsions with precise control over particle size and uniformity. Leveraging the microreactor's advantages in mass transfer and mixing, we established an empirical correlation to predict and adjust nanoemulsion properties. Optimized operational parameters enabled the synthesis of stable dasatinib nanoemulsions with narrow size distributions and mean diameters below 20 nm, maintaining their stability and transparency under various storage conditions.