Palladium catalyzed regioselective distal C (sp2)–H functionalization

Abstract

The selective functionalization of C−H bonds in arenes remains a challenging task in organic synthesis. While directing group (DG)-assisted strategies for proximal C−H activation are well-established, distal meta and para-C−H functionalization has proven more elusive and has attracted significant interest. Palladium-catalyzed C−H activation, in particular, has emerged as a promising approach for achieving site-selectivity in these transformations. This review provides a comprehensive overview of recent advances in palladium-catalyzed distal C−H functionalization, delving into mechanistic details and the scope of these strategies. By summarizing the successes and challenges in this field, we aim to illuminate potential avenues for future research and development in synthetic methodology.