Integrating lanthanide coordination polymer ratiometric fluorescence biosensors with a concatenated DNA circuit for locus-specific N6-methyladenosine quantification

Ping Nie; Ke Chen; Guohui Cao; Ensheng Xu; Pin Wang; Qingwang Xue

doi:10.1039/D4CC06742H

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Integrating lanthanide coordination polymer ratiometric fluorescence biosensors with a concatenated DNA circuit for locus-specific N⁶-methyladenosine quantification†

Ping Nie,‡^a Ke Chen,‡^b Guohui Cao,‡^ad Ensheng Xu,*^a Pin Wang*^c and Qingwang Xue

*^a

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* Corresponding authors

^a Department of Chemistry, Liaocheng University, Liaocheng, Shandong, China
E-mail: xuensheng@lcu.edu.cn, xueqingwang1983@163.com
Fax: +86-635-8239001
Tel: +86-635-8239001

^b Department of Biotechnology, College of Engineering, The University of Suwon, Hwaseong 18323, Korea

^c Neurology of Department, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P. R. China
E-mail: wangpin1023@126.com

^d College of Chemical Engineering and Technology, College of Technology and Data, Yantai Nanshan University, Yantai, P. R. China

Abstract

Herein, we developed a lanthanide coordination polymer (LnCP) ratiometric fluorescent biosensor integrated with a click chemistry-powered concatenated DNA circuit for accurate and sensitive monitoring of locus-specific m⁶A in cancer cells and tissues.

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Article information

DOI: https://doi.org/10.1039/D4CC06742H
Article type: Communication
Submitted: 26 Dec 2024
Accepted: 05 Feb 2025
First published: 06 Feb 2025

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Chem. Commun., 2025, Advance Article

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Integrating lanthanide coordination polymer ratiometric fluorescence biosensors with a concatenated DNA circuit for locus-specific N⁶-methyladenosine quantification

P. Nie, K. Chen, G. Cao, E. Xu, P. Wang and Q. Xue, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D4CC06742H

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