Fluorescence probe for the fast and sensitive detection and imaging of ONOO− via regulation of charge distribution

Yanhong Lin; Bingling Zhang; Xiaoli Yu; Chang Lu; Guozhen Zhang; Xiaole Zhou; Leyu Wang

doi:10.1039/D5CC00055F

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Fluorescence probe for the fast and sensitive detection and imaging of ONOO⁻via regulation of charge distribution†

Yanhong Lin,^a Bingling Zhang,^a Xiaoli Yu,^a Chang Lu,^a Guozhen Zhang,

*^b Xiaole Zhou

*^a and Leyu Wang

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, P. R. China
E-mail: zhouxiaole@buct.edu.cn, lywang@mail.buct.edu.cn

^b Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, Anhui, P. R. China
E-mail: guozhen@ustc.edu.cn

Abstract

A rapid, sensitive and selective ONOO⁻ probe L-C-CH₃-Cy5 was developed using a cyanine dye bearing a meso-quinolinium group. The quinolinium group plays a pivotal role in the performance, as it modulates the signal-to-noise ratio and the reactivity of L-C-CH₃-Cy5 towards ONOO⁻, thereby substantially improving both sensitivity and selectivity.

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Article information

DOI: https://doi.org/10.1039/D5CC00055F
Article type: Communication
Submitted: 04 Jan 2025
Accepted: 12 Feb 2025
First published: 12 Feb 2025

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Chem. Commun., 2025, Advance Article

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Fluorescence probe for the fast and sensitive detection and imaging of ONOO⁻ via regulation of charge distribution

Y. Lin, B. Zhang, X. Yu, C. Lu, G. Zhang, X. Zhou and L. Wang, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC00055F

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