Cascade heteroarylation/annulation of arylphosphonic acid monoesters with benzothiophenes: access to benzothieno-fused oxaphosphacycles

Abstract

Sequential C–H/C–H and C–H/O–H cross-dehydrogenative coupling of arylphosphonic acid monoesters with benzothiophenes has been achieved through Ru(II) catalysis to afford benzothieno-fused oxaphosphacycles. This strategy can be extended to the cross-coupling of vinylphosphonic acid monoesters. The site-selectivity, substrate scope, functional group tolerance and photophysical properties of the products are the important features of the reaction.