Polymorphism in novel symmetric and asymmetric bis-hydrazone derivatives

Abstract

This study describes conformational polymorphism in seven novel symmetric and asymmetric bis-hydrazone derivates, which contain a flexible CN–NC–CN–NC spine. Taking a cue from the computational study, solvent-mediated crystallization by slow evaporation generated polymorphs of the compounds. The choice of solvent determines the formation of polymorphs of the compounds in this study either concomitantly or exclusively. All the polymorphs have been characterized structurally by single crystal X-ray diffraction technique.