Racemic peptide assembly boosts biocatalysis

Abstract

Racemic assembly of minimalistic heterochiral tripeptides boosts their biocatalytic activity for ester hydrolysis. The amino acidic sequences are bioinspired and feature histidine (His) as a catalytically active residue, and the diphenylalanine (Phe-Phe) motif to drive self-assembly into anisotropic nanostructures that gel. This study thus provides key insights for the design of green biocatalysts with improved activity.

Graphical abstract: Racemic peptide assembly boosts biocatalysis

Supplementary files

Article information

Article type
Communication
Submitted
08 Dec 2024
Accepted
11 Feb 2025
First published
13 Feb 2025

Org. Biomol. Chem., 2025, Advance Article

Racemic peptide assembly boosts biocatalysis

M. C. Mañas-Torres, P. Alletto, S. Adorinni, A. V. Vargiu, L. Álvarez de Cienfuegos and S. Marchesan, Org. Biomol. Chem., 2025, Advance Article , DOI: 10.1039/D4OB01987C

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