A palladium(II)/Lewis acid-catalyzed C–H olefination of 2-benzamidopyridine 1-oxide with acrylates followed by intramolecular aza-Michael addition for the synthesis of isoindolinones has been developed. The use of a heterobimetallic Pd(II)/Cu(II) catalyst enhances the efficiency of the reaction, enabling the synthesis of a potential anti-sedative agent.
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D. M. Patel, R. N. Patel, N. B. Rathod, S. D. Patel, D. G. Thakur, M. A. Sonawane and S. C. Ghosh, Org. Biomol. Chem., 2025, Advance Article , DOI: 10.1039/D5OB00021A
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