Photoinduced borylation of N-tosylhydrazones and application in drug derivation

Abstract

The formation of carbon–boron bonds is a fundamental transformation in organic synthesis and the direct conversion of N-tosylhydrazones by photoinduced reactions is also a convenient and novel method. Herein, we report a mild strategy to access borylated compounds from aldehyde-derived N-tosylhydrazones, which proceeds without the need for any transition-metal catalysts under photoinduced conditions. Gram-scale synthesis and post-functionalization of drug analogues were achieved successfully, providing an approach to facilitate the fast modification of drugs.