Intermolecular amination of ethyl benzo ylacetate via photocatalytic nitrene transfer reactions

Abstract

In this study, we report on a C–H functionalization of 1,3-dicarbonyl compounds via a photocatalytic nitrene transfer reaction. A wide range of 1,3-dicarbonyl substrates and iodinanes were found compatible with the reaction conditions to directly afford the C–H functionalization products without the need of preformation of nucleophilic enolate equivalents. Additionally, a comprehensive series of synthetic applications and control experiments were conducted, thereby further extending the practical utility of this approach.