FeCl3 promoted cycloisomerization of 1,6-dienes

Zhongjian Du; Chenlei Ji; Xu Wang; Zhenyu Wang; Zhenguo Guo; Yang'en You

doi:10.1039/D4QO02201G

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

FeCl₃ promoted cycloisomerization of 1,6-dienes†

Zhongjian Du,^a Chenlei Ji,^a Xu Wang,^a Zhenyu Wang,^b Zhenguo Guo*^a and Yang'en You

*^a

Author affiliations

* Corresponding authors

^a School of Chemistry and Chemical Engineering, Hefei University of Technology and Anhui Province Key Laboratory of Value-Added Catalytic Conversion and Reaction Engineering, Hefei 230009, China
E-mail: gzg2020@hfut.edu.cn, chmyouy@hfut.edu.cn

^b Anhui Province Key Lab of Green Manufacturing in Phosegene Industry, Caijiashan Fine Chem Pk, Xinhang 242235, China

Abstract

A highly selective cycloisomerization of 1,6-dienes by FeCl₃ catalysis has been developed. Both symmetric and unsymmetric dienes could undergo this cycloisomerization through a carbocation pathway activated by Lewis acid FeCl₃. This protocol offers a green approach to access α-alkenyl-tetrahydropyridine compounds with high yields and good selectivity.

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/D4QO02201G
Article type: Research Article
Submitted: 22 Nov 2024
Accepted: 27 Jan 2025
First published: 29 Jan 2025

Download Citation

Org. Chem. Front., 2025, Advance Article

Permissions

Request permissions

FeCl₃ promoted cycloisomerization of 1,6-dienes

Z. Du, C. Ji, X. Wang, Z. Wang, Z. Guo and Y. You, Org. Chem. Front., 2025, Advance Article , DOI: 10.1039/D4QO02201G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Organic Chemistry Frontiers