From the journal:

Organic Chemistry Frontiers

Total synthesis and stereochemical assignment of cubensci acid†

Yangyang Jiang,a   Junyang Liu ORCID logo *b  and  Tao Ye ORCID logo *ac  

* Corresponding authors

a State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China
E-mail: yet@pkusz.edu.cn

b School of Pharmacy and Food Engineering, Wuyi University, Jiangmen, China
E-mail: liujy@wyu.edu.cn

c QianYan (Shenzhen) Pharmatech. Ltd., Shenzhen 518172, China

Abstract

The absolute configuration of cubensic acid was predicted using the “Biochemistry-based Rule” and confirmed through total synthesis. Key steps in the synthesis included a titanium-mediated aldol reaction, a Paterson anti-aldol reaction, and a vinylogous Mukaiyama aldol reaction.

Graphical abstract: Total synthesis and stereochemical assignment of cubensci acid

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D5QO00545K
Article type
Research Article
Submitted
19 Mar 2025
Accepted
20 Apr 2025
First published
23 Apr 2025

Org. Chem. Front., 2025, Advance Article

Permissions

Request permissions

Total synthesis and stereochemical assignment of cubensci acid

Y. Jiang, J. Liu and T. Ye, Org. Chem. Front., 2025, Advance Article , DOI: 10.1039/D5QO00545K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements