Photocatalytic α-nucleophilic fluorination of α,β-unsaturated carbonyl compounds

Abstract

We report redox-neutral photocatalytic α-nucleophilic fluorination of α,β-unsaturated carbonyl compounds, in which an α-carbonyl cation is involved, under mild conditions. The protocol offers practical and efficient access to α-fluorinated carbonyl compounds and has demonstrated potential applications in the late-stage fluorination of bioactive molecules.