The conversion of 6-farnesyl-5,7-dihydroxy-4-methylphthalide (5) into mycophenolic acid (1) proceeds through the hydroxy-ketone (11) by oxidation of the central double bond.
L. Colombo, C. Gennari and C. Scolastico, J. Chem. Soc., Chem. Commun., 1978, 434 DOI: 10.1039/C39780000434
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