Interactions of tetrakis-µ-acetato-dirhodium(II) with adenine nucleosides and nucleotides

Abstract

Reactions of the antitumour complex [Rh₂(O₂CMe)₄] with adenine nucleosides and nucleotides have been studied in aqueous solutions. Both 1 : 1 and 1 : 2 solid adducts have been isolated and characterized by elemental analyses and i.r., visible, and ¹H n.m.r. spectra. The results indicate that the 1 : 1 adenine derivatives form polymeric bridged adducts with both N(1) and N(7) sites bonded to Rh^II. The only exception is tetra-acetyladenosine which forms 1 : 2 adducts in which only the N(7) site is involved in bonding to Rh^II.