Issue 12, 1987

β-Oxidofunctionalized organolithium intermediates from ketones: a simple new access

Abstract

Chloromethyl-lithium generated in situ, reacts at –78 °C with ketones (5) to afford, after lithiation with lithium naphthalenide, β-oxidoalkyl-lithium compounds (1), which on reaction with electrophiles (deuterium oxide, dimethyl disulphide, carbon dioxide, cyclohexanone, and allyl bromide) yield bifunctionalized compounds (6).

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1987, 915-916

β-Oxidofunctionalized organolithium intermediates from ketones: a simple new access

J. Barluenga, J. L. Fernández-Simón, J. M. Concellón and M. Yus, J. Chem. Soc., Chem. Commun., 1987, 915 DOI: 10.1039/C39870000915

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