We describe the synthesis of variously substituted 8,9,10,11-tetraoxatricyclo[5.2.1.12,6]undecan-4-ones. Several of these stable ozonides exhibited activity (IC50′s of 10–20 µg cm–3) against a chloroquine-resistant strain of the malaria parasite Plasmodium falciparum.
L. de Almeida Barbosa, D. Cutler, J. Mann, G. C. Kirby and D. C. Warhurst, J. Chem. Soc., Perkin Trans. 1, 1992, 3251 DOI: 10.1039/P19920003251
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