[Tyr-3-ψ(CS-NH)-Ala-4]RA-VII 3, [Tyr-3-ψ(CS-NH)-Ala-4; Tyr-6-ψ(CS-NH)-D-Ala-1]RA-VII 4, [Tyr-3-ψ(CS-NH)-Ala-4]RA-V 7 and [Tyr-3-ψ(CS-NH)-Ala-4]RA-X methyl ester 8 have been prepared from corresponding RAs, and they showed more promising in vitro antitumour activity than the parent compounds.
Y. Hitotsuyanagi, J. Suzuki, Y. Matsumoto, K. Takeya and H. Itokawa, J. Chem. Soc., Perkin Trans. 1, 1994, 1887 DOI: 10.1039/P19940001887
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