Chlorodifluoromethyl ketones reacted with diazomethane to afford epoxides in high yield; upon treatment with butyllithium, the epoxides underwent efficient ring opening to afford 3,3-difluoro-2-alkyl-alken-1-ols, suitable substrates for sigmatropic rearrangement leading to compounds containing a CF2 group in mid-chain.
J. Bégué, D. Bonnet-Delpon, J. M. Percy, M. H. Rock and R. D. Wilkes, J. Chem. Soc., Chem. Commun., 1995, 1857 DOI: 10.1039/C39950001857
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