Issue 22, 1998

The effect of strain on reactivity: poor leaving groups increase strain-induced inhibition of alkene-forming elimination

Abstract

Elimination to form a carbon–carbon double bond exocyclic to a cyclopropane ring is inhibited by factors which increase from 1.4 to 104.5 as the leaving group becomes poorer; strain induced in the transition structure can amount to some 50% of the enthalpy difference between strained and unstrained products.

Article information

Article type
Paper

Chem. Commun., 1998, 2481-2482

The effect of strain on reactivity: poor leaving groups increase strain-induced inhibition of alkene-forming elimination

L. Volta and C. J. M. Stirling, Chem. Commun., 1998, 2481 DOI: 10.1039/A807506I

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